TP53 stimulates NDRG1 gene expression

Stable Identifier
R-HSA-5633314
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates NDRG1 gene expression
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Binding of TP53 (p53) to the NDRG1 gene promoter stimulates NDRG1 expression (Stein et al. 2004, Zhang et al. 2007). NDRG1 may positively regulate TP53-mediated apoptosis (Stein et al. 2004) or TP53-mediated cell cycle arrest (Zhang et al. 2007). The exact function of NDRG1 has not been elucidated. Most studies suggest that NDRG1 has a tumor suppressive role, but there are conflicting reports, showing that NDRG1 may act as an oncogene in some settings (reviewed by Liu et al. 2012, Sun and Cao 2013).
Literature References
PubMed ID Title Journal Year
24260043 N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)

Cao, L, Song, Y

Oncol Lett 2013
17442733 p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion

Liu, L, Chen, J, Xiao, L, Wang, JY, Zou, T, Turner, DJ, Marasa, BS, Zhang, AH, Rao, JN

Am. J. Physiol., Cell Physiol. 2007
23671130 Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors

Zhao, Q, Sahni, S, Sun, J, Richardson, DR, Yue, F, Zhang, D, Bae, DH, Kovacevic, Z, Zheng, Y, Zheng, M, Jansson, P

Carcinogenesis 2013
15377670 NDRG1 is necessary for p53-dependent apoptosis

Herzog, B, Liang, P, Jackson, RS, Thomas, EK, Wang, M, Westfall, MD, Rocheleau, JV, Stein, S

J. Biol. Chem. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:NDRG1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2014-10-31)
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