Reactome | TP53 inhibits BIRC5 expression

TP53 inhibits BIRC5 expression

Stable Identifier

R-HSA-6797763

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 inhibits BIRC5 expression (Homo sapiens)

General

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Upon binding to the p53 response element in the promoter of the BIRC5 (survivin) gene, TP53 (p53) inhibits transcription of BIRC5, an inhibitor of apoptosis (Hoffman et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11714700	Transcriptional repression of the anti-apoptotic survivin gene by wild type p53 Zilfou, JT, Murphy, M, Chen, J, Biade, S, Hoffman, WH	J. Biol. Chem.	2002

Participants

Input

BIRC5 Gene [nucleoplasm] (Homo sapiens)

Output

BIRC5 [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)

This event is regulated

Negatively by

Regulator

p-S15,S20-TP53 Tetramer:BIRC5 Gene [nucleoplasm] (Homo sapiens)

Active Unit

p-S15,S20-TP53 Tetramer [nucleoplasm]

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-09-16)

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