TP53 stimulates BCL2L14 gene expression

Stable Identifier
R-HSA-6791323
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates BCL2L14 gene expression
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Binding of TP53 (p53) to p53 response element(s) in the first intron and, possibly, the promoter region of BCL2L14 stimulates transcription of the BCL2L14 gene. BCL2L14 (BCLG) is a BCL2 family member with an unknown function and a proposed but uncertain pro-apoptotic role (Guo et al. 2001, Giam et al. 2012).
Literature References
PubMed ID Title Journal Year
15958553 A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network

Miled, C, Pontoglio, M, Garbay, S, Yaniv, M, Weitzman, JB

Cancer Res. 2005
23059823 Bcl-2 family member Bcl-G is not a proapoptotic protein

Giam, M, Okamoto, T, Mintern, JD, Strasser, A, Bouillet, P

Cell Death Dis 2012
11054413 Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

Guo, B, Godzik, A, Reed, JC

J. Biol. Chem. 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:BCL2L14 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-08-20)
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