Reactome | TP53 stimulates BCL2L14 gene expression

TP53 stimulates BCL2L14 gene expression

Stable Identifier

R-HSA-6791323

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 stimulates BCL2L14 gene expression (Homo sapiens)

General

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Binding of TP53 (p53) to p53 response element(s) in the first intron and, possibly, the promoter region of BCL2L14 stimulates transcription of the BCL2L14 gene. BCL2L14 (BCLG) is a BCL2 family member with an unknown function and a proposed but uncertain pro-apoptotic role (Guo et al. 2001, Giam et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23059823	Bcl-2 family member Bcl-G is not a proapoptotic protein Giam, M, Okamoto, T, Mintern, JD, Strasser, A, Bouillet, P	Cell Death Dis	2012
15958553	A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network Miled, C, Pontoglio, M, Garbay, S, Yaniv, M, Weitzman, JB	Cancer Res.	2005
11054413	Bcl-G, a novel pro-apoptotic member of the Bcl-2 family Guo, B, Godzik, A, Reed, JC	J. Biol. Chem.	2001