TP53 stimulates BCL2L14 gene expression

Stable Identifier
R-HSA-6791323
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of TP53 (p53) to p53 response element(s) in the first intron and, possibly, the promoter region of BCL2L14 stimulates transcription of the BCL2L14 gene. BCL2L14 (BCLG) is a BCL2 family member with an unknown function and a proposed but uncertain pro-apoptotic role (Guo et al. 2001, Giam et al. 2012).

Literature References
PubMed ID Title Journal Year
23059823 Bcl-2 family member Bcl-G is not a proapoptotic protein

Giam, M, Okamoto, T, Mintern, JD, Strasser, A, Bouillet, P

Cell Death Dis 2012
15958553 A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network

Miled, C, Pontoglio, M, Garbay, S, Yaniv, M, Weitzman, JB

Cancer Res. 2005
11054413 Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

Guo, B, Godzik, A, Reed, JC

J. Biol. Chem. 2001
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created