Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TNFSF8 [plasma membrane]
Stable Identifier
R-HSA-5667148
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tumor necrosis factor ligand superfamily member 8, TNFL8_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
TNFSF8 binds TNFRSF8 (Homo sapiens)
TNFSF8 [plasma membrane] (Homo sapiens)
TNFSF8:TNFRSF8 [plasma membrane] (Homo sapiens)
TNFSF8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32971 TNFSF8
Gene Names
TNFSF8, CD30L, CD30LG
Chain
chain:1-234
Reference Genes
BioGPS Gene:944 TNFSF8
COSMIC (genes):TNFSF8 TNFSF8
CTD Gene:944 TNFSF8
dbSNP Gene:944 TNFSF8
ENSEMBL:ENSG00000106952 TNFSF8
ENSEMBL_homo_sapiens_GENE:ENSG00000106952.8 TNFSF8
HGNC:11938 TNFSF8
KEGG Gene (Homo sapiens):944 TNFSF8
Monarch:944 TNFSF8
NCBI Gene:944 TNFSF8
OMIM:603875 TNFSF8
Reference Transcript
RefSeq:NM_001244.3 TNFSF8
Other Identifiers
11737777_at
11737778_at
17097653
207216_PM_at
207216_at
235735_PM_at
235735_at
3222147
3222148
3222149
3222150
3222151
3222152
3222153
3222159
3222161
3222162
3222163
33012_at
49886_at
8163629
87425_at
944
A_23_P169257
GE591251
GE631622
GE80298
GO:0002376
GO:0005102
GO:0005125
GO:0005164
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006351
GO:0006355
GO:0006955
GO:0007154
GO:0007165
GO:0007267
GO:0016020
GO:0023052
GO:0030154
GO:0042129
GO:0043374
GO:0045944
GO:0048018
GO:0048856
GO:0050830
GO:0098542
GO:0098772
HMNXSV003049131
Hs.101370.0.A1_3p_at
ILMN_1761778
L09753_at
PH_hs_0022857
TC09001516.hg
g4507606_3p_at
Participates
as a component of
TNFSF8:TNFRSF8 [plasma membrane] (Homo sapiens)
as an input of
TNFSF8 binds TNFRSF8 (Homo sapiens)
Inferred To
Tnfsf8 [plasma membrane]
(Mus musculus)
Tnfsf8 [plasma membrane]
(Rattus norvegicus)
TNFSF8 [plasma membrane]
(Bos taurus)
TNFSF8 [plasma membrane]
(Canis familiaris)
TNFSF8 [plasma membrane]
(Gallus gallus)
TNFSF8 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001235.1
OpenTargets
ENSG00000106952
HPA
ENSG00000106952-TNFSF8
GeneCards
P32971
Ensembl
ENST00000223795
,
ENSP00000223795
,
ENSG00000106952
PRO
P32971
Pharos - Targets
P32971
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07325 CXCL9
1
CXCL9 [extracellular region]
(R-HSA-373856)
0.556
3
UniProt:O95393 BMP10
2
BMP10(22-424) [extracellular region]
(R-HSA-2396409)
BMP10 [extracellular region]
(R-HSA-8858374)
0.556
3
UniProt:Q9BRY0 SLC39A3
1
SLC39A3 [plasma membrane]
(R-HSA-442426)
0.527
3
UniProt:Q8WUJ1 NEUFC
0.527
3
UniProt:Q6UX07 DHR13
0.527
3
UniProt:Q8NHS3 MFSD8
0.527
2
UniProt:Q14118 DAG1
10
GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931659)
GlcNAc,1,2-Man-DAG1 [Golgi lumen]
(R-HSA-5617087)
Man-DAG1 [Golgi lumen]
(R-HSA-8931888)
GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931656)
GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-8931673)
Man-DAG1 [endoplasmic reticulum lumen]
(R-HSA-5615647)
DAG1(30-653) [endoplasmic reticulum lumen]
(R-HSA-8931890)
DAG1(30-653) [cytosol]
(R-HSA-5615641)
DAG1(30-653) [extracellular region]
(R-HSA-2328152)
DAG1(654-895) [plasma membrane]
(R-HSA-2328154)
0.527
3
UniProt:Q13535 ATR
1
ATR [nucleoplasm]
(R-HSA-912443)
0.527
3
UniProt:P02042 HBD
1
HBD [cytosol]
(R-HSA-1008218)
0.527
3
UniProt:P12259 F5
15
factor V [platelet alpha granule lumen]
(R-HSA-141766)
F5(535-737) [extracellular region]
(R-HSA-5605103)
F5(335-534) [extracellular region]
(R-HSA-5605102)
F5(29-334) [extracellular region]
(R-HSA-5605101)
F5(29-534) [extracellular region]
(R-HSA-5605104)
factor V activation peptide [extracellular region]
(R-HSA-140787)
factor V [extracellular region]
(R-HSA-140697)
factor Va heavy chain [extracellular region]
(R-HSA-140691)
factor Va light chain [extracellular region]
(R-HSA-140690)
factor Va heavy chain [plasma membrane]
(R-HSA-140653)
Factor V precursor [endoplasmic reticulum lumen]
(R-HSA-5689447)
p-Factor V precursor [endoplasmic reticulum lumen]
(R-HSA-8956960)
Factor V precursor [COPII-coated ER to Golgi transport vesicle]
(R-HSA-5689792)
Factor V precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689793)
factor Va light chain [plasma membrane]
(R-HSA-140660)
0.527
3
UniProt:Q9BZM6 ULBP1
1
ULBP1 [plasma membrane]
(R-HSA-199509)
0.527
3
UniProt:Q15768 EFNB3
2
p-Y318,Y323,Y337-EFNB3 [plasma membrane]
(R-HSA-3928388)
EFNB3 [plasma membrane]
(R-HSA-2682319)
0.527
2
UniProt:Q9C0C4 SEM4C
0.527
2
UniProt:Q9UBI1 COMMD3
4
COMMD3 [nucleoplasm]
(R-HSA-8955108)
COMMD3 [cytosol]
(R-HSA-8955113)
COMMD3 [extracellular region]
(R-HSA-6806501)
COMMD3 [ficolin-1-rich granule lumen]
(R-HSA-6801405)
0.527
3
UniProt:Q9BZM5 ULBP2
2
cleaved GPI-ULBP2 [extracellular region]
(R-HSA-8941023)
GPI-ULBP2 [plasma membrane]
(R-HSA-8940750)
0.527
2
UniProt:Q9BZM4 ULBP3
1
ULBP3 [plasma membrane]
(R-HSA-198076)
0.527
3
UniProt:Q9NZ53 PODXL2
2
OSulf-Y97,118-PODXL2 [Golgi lumen]
(R-HSA-8954273)
PODXL2 [Golgi lumen]
(R-HSA-8954248)
0.527
2
UniProt:P17706 PTPN2
3
p-PTPN2 [cytosol]
(R-HSA-9836510)
PTPN2 [nucleoplasm]
(R-HSA-9008891)
PTPN2 [cytosol]
(R-HSA-997292)
0.527
2
UniProt:P51956 NEK3
0.527
2
UniProt:P41273 TNFSF9
1
TNFSF9 [plasma membrane]
(R-HSA-5667144)
0.527
3
UniProt:Q96DA2 RAB39B
3
GGC-RAB39B [Golgi membrane]
(R-HSA-8877796)
GGC-RAB39B [cytosol]
(R-HSA-8874006)
RAB39B [cytosol]
(R-HSA-8873679)
0.527
2
UniProt:Q8N441 FGFRL1
1
FGFRL1 [plasma membrane]
(R-HSA-197650)
0.527
2
UniProt:P69905 HBA1
4
CO-H+-HBA1 [cytosol]
(R-HSA-1237026)
HBA1 [cytosol]
(R-HSA-1008268)
HBA1 [endocytic vesicle lumen]
(R-HSA-2230966)
HBA1 [extracellular region]
(R-HSA-2168862)
0.527
3
UniProt:Q16625 OCLN
4
OCLN [cell junction]
(R-HSA-2160944)
OCLN(1-320) [plasma membrane]
(R-HSA-351854)
OCLN(321-522) [plasma membrane]
(R-HSA-351873)
OCLN [plasma membrane]
(R-HSA-351846)
0.527
3
UniProt:Q8N8Z6 DCBD1
0.527
2
UniProt:P98172 EFNB1
2
p-Y324,Y329,Y343-EFNB1 [plasma membrane]
(R-HSA-3928412)
EFNB1 [plasma membrane]
(R-HSA-2682327)
0.527
3
UniProt:O14657 TOR1B
1
TOR1B [cytosol]
(R-HSA-8862861)
0.527
3
UniProt:O75879 GATB
0.527
2
UniProt:Q96BW9 TAM41
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text