Reactome | GGC-RAB39B [cytosol]

GGC-RAB39B [cytosol]

Stable Identifier

R-HSA-8874006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ras-related protein Rab-39B, RB39B_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
      - DENND5A,B exchange GTP for GDP on RAB39 (Homo sapiens)
        
        GGC-RAB39:GDP:GDIs,CHMs [cytosol] (Homo sapiens)
        
        GGC-RAB39:GDP [cytosol] (Homo sapiens)
        
        GGC-RAB39 [cytosol] (Homo sapiens)
        
        GGC-RAB39B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96DA2 RAB39B

Gene Names

RAB39B

Chain

chain:1-213

Reference Genes

BioGPS Gene:116442 RAB39B

COSMIC (genes):RAB39B RAB39B

CTD Gene:116442 RAB39B

dbSNP Gene:116442 RAB39B

ENSEMBL:ENSG00000155961 RAB39B

HGNC:16499 RAB39B

Monarch:116442 RAB39B

NCBI Gene:116442 RAB39B

OMIM:300774 RAB39B

UCSC:Q96DA2 RAB39B

Reference Transcript

RefSeq:NM_171998.3 RAB39B

Other Identifiers

116442

11728848_at

11728849_at

11728850_at

11728851_s_at

17115777

230075_PM_at

230075_at

238695_PM_s_at

238695_s_at

4027753

4027754

4027755

4027756

4027757

4027758

4027759

4027760

58091_at

61352_at

75526_at

8176230

A_23_P159877

A_24_P408603

GE541416

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005794

GO:0005886

GO:0006914

GO:0008092

GO:0010506

GO:0015031

GO:0016192

GO:0016787

GO:0030659

GO:0031410

GO:0031489

GO:0031982

GO:0032482

GO:0034330

GO:0043005

GO:0043226

GO:0050808

HMNXSV003036085

Hs.144042.0.A1_3p_at

Hs.24970.0.A1_3p_s_at

Hs.24970.0.A1_3p_x_at

ILMN_1811889

TC0X001550.hg

Participates

as a candidate of

Other forms of this molecule

GGC-RAB39B [Golgi membrane]

RAB39B [cytosol]

Inferred To

rab39b [cytosol] (Xenopus tropicalis)

RAB39B [cytosol] (Canis familiaris)

RAB39B [cytosol] (Sus scrofa)

Rab39 [cytosol] (Drosophila melanogaster)

GGC-RAB39B [cytosol] (Bos taurus)

GGC-RAB39B [cytosol] (Caenorhabditis elegans)

GGC-RAB39B [cytosol] (Dictyostelium discoideum)

GGC-RAB39B [cytosol] (Gallus gallus)

GGC-RAB39B [cytosol] (Mus musculus)

GGC-RAB39B [cytosol] (Plasmodium falciparum)

Homologues of GGC-RAB39B [cytosol] (Dictyostelium discoideum)

rab39bb [cytosol] (Danio rerio)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 211

Coordinate

211

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 213

Coordinate

213

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

ENSEMBL

ENSP00000358466, ENST00000369454

OpenTargets

ENSG00000155961

HPA

ENSG00000155961-RAB39B

PRO

Q96DA2

Pharos - Targets

Q96DA2

Orphanet

RAB39B

PDB

6S5F

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.666	4
UniProt:Q96T51 RUFY1	3	p-Y389,400-RUFY1 [cytosol] (R-HSA-8871352) RUFY1 [cytosol] (R-HSA-8871374) p-Y389,400-RUFY1 [early endosome membrane] (R-HSA-5215951)	0.666	4
UniProt:P46059 SLC15A1	1	SLC15A1 [plasma membrane] (R-HSA-428022)	0.527	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.527	2
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.527	2