TNFSF8 binds TNFRSF8

Stable Identifier
R-HSA-8856189
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CD30L binds CD30, CD153 binds CD30
ReviewStatus
5/5
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TNFSF8 binds TNFRSF8
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Tumor necrosis factor receptor superfamily 8 (TNFRSF8, CD30) and its ligand TNFSF8 (CD30 ligand, CD30L, CD153) are interacting cell-surface glycoproteins. TNFRSF8 is expressed on activated CD4 and CD8 T cells and B cells. It is a marker for Hodgkin's syndrome. TNFRSF8 signaling regulates hymocyte survival (Blazar et al. 2004) and peripheral T cell responses, controlling T cell survival and down-regulating cytolytic capacity (Duckett et al. 1997, Kurts et al. 1999, Telford et al. 1997).
Literature References
PubMed ID Title Journal Year
8871664 Reverse signaling via CD30 ligand

Goodwin, RG, Wiley, SR, Smith, CA

J. Immunol. 1996
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Orthologous Events
TNFSF8 binds TNFRSF8 (Bos taurus)
TNFSF8 binds TNFRSF8 (Canis familiaris)
TNFSF8 binds TNFRSF8 (Gallus gallus)
TNFSF8 binds TNFRSF8 (Mus musculus)
TNFSF8 binds TNFRSF8 (Rattus norvegicus)
Authored
Garapati, P V  (2016-05-19)
Reviewed
Virgen-Slane, R  (2015-05-12)
Ware, CF  (2015-05-12)
Created
Garapati, P V  (2016-02-09)
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