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COMMD3 [cytosol]
Stable Identifier
R-HSA-8955113
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
COMM domain-containing protein 3, COMD3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
COMMDs:CCDC22 [cytosol] (Homo sapiens)
COMMDs [cytosol] (Homo sapiens)
COMMD3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBI1 COMMD3
Gene Names
COMMD3, BUP, C10orf8
Chain
chain:1-195
Reference Genes
BioGPS Gene:23412 COMMD3
COSMIC (genes):COMMD3 COMMD3
CTD Gene:23412 COMMD3
dbSNP Gene:23412 COMMD3
ENSEMBL:ENSG00000148444 COMMD3
HGNC:23332 COMMD3
KEGG:hsa:23412 COMMD3
Monarch:23412 COMMD3
NCBI Gene:23412 COMMD3
OMIM:616700 COMMD3
UCSC:Q9UBI1 COMMD3
Reference Transcript
RefSeq:NM_012071.3 COMMD3
Other Identifiers
11723710_a_at
11754783_x_at
218048_PM_at
218048_at
23412
3238467
3238468
3238469
3238472
3238473
3238474
3238475
3238476
3238477
3238478
3238479
3238480
3238481
3238482
3238483
3238484
3238485
3238486
3238487
3238488
3238492
45764_at
7926596
85487_at
A_14_P107846
A_23_P138514
GE58452
GO:0005515
GO:0005576
GO:0005634
GO:0005737
GO:0006814
GO:0043226
GO:1904813
HMNXSV003056228
ILMN_1690392
PH_hs_0027114
TC10002934.hg
g6912277_3p_at
Participates
as a candidate of
COMMDs [cytosol] (Homo sapiens)
Other forms of this molecule
COMMD3 [nucleoplasm]
COMMD3 [extracellular region]
COMMD3 [ficolin-1-rich granule lumen]
Inferred To
commd3 [cytosol]
(Danio rerio)
commd3 [cytosol]
(Dictyostelium discoideum)
commd3 [cytosol]
(Xenopus tropicalis)
COMMD3 [cytosol]
(Bos taurus)
COMMD3 [cytosol]
(Gallus gallus)
COMMD3 [cytosol]
(Sus scrofa)
Dmel\CG12106 [cytosol]
(Drosophila melanogaster)
Commd3 [cytosol]
(Mus musculus)
Commd3 [cytosol]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSG00000148444
,
ENSP00000366032
,
ENST00000376836
OpenTargets
ENSG00000148444
GeneCards
COMMD3
HPA
ENSG00000148444-COMMD3
PRO
Q9UBI1
Pharos - Targets
Q9UBI1
GlyGen
Q9UBI1
PDB
8F2U
,
8F2R
,
8P0W
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96PC5 MIA2
1
MIA2 [endoplasmic reticulum membrane]
(R-HSA-9637821)
0.527
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:P32971 TNFSF8
1
TNFSF8 [plasma membrane]
(R-HSA-5667148)
0.527
3
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