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p-Y318,Y323,Y337-EFNB3 [plasma membrane]
Stable Identifier
R-HSA-3928388
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phospho-Ephrin-B3, EFNB3_HUMAN, p-EFNB3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
Ephrin signaling (Homo sapiens)
EFNB:GRB4 binds GIT1 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
GIT1 binds bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
PAK binds RAC and bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
SFKs phosphorylate EFNBs (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
p-EFNB binds GRB4 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y318,Y323,Y337-EFNB3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15768 EFNB3
Gene Names
EFNB3, EPLG8, LERK8
Chain
signal peptide:1-27, chain:28-340
Reference Genes
BioGPS Gene:1949 EFNB3
COSMIC (genes):EFNB3 EFNB3
CTD Gene:1949 EFNB3
dbSNP Gene:1949 EFNB3
ENSEMBL:ENSG00000108947 EFNB3
HGNC:3228 EFNB3
KEGG:hsa:1949 EFNB3
Monarch:1949 EFNB3
NCBI Gene:1949 EFNB3
OMIM:602297 EFNB3
UCSC:Q15768 EFNB3
Reference Transcript
RefSeq:NM_001406.3 EFNB3
Other Identifiers
11722318_a_at
11722319_a_at
11722320_a_at
16830653
1949
205031_PM_at
205031_at
210883_PM_x_at
210883_x_at
3708992
3708993
3708995
3708997
3708998
3708999
3709001
3709002
3709003
3709004
3709005
3709006
3709007
469_at
8004571
A_14_P104467
A_23_P433588
A_24_P940006
GE59333
GE890359
GO:0001618
GO:0002376
GO:0003824
GO:0005005
GO:0005515
GO:0005886
GO:0007267
GO:0007399
GO:0007411
GO:0007628
GO:0016020
GO:0016198
GO:0016740
GO:0023052
GO:0030154
GO:0031295
GO:0042734
GO:0046718
GO:0046875
GO:0048013
GO:0048856
GO:0050771
GO:0050806
GO:0060089
GO:0098686
GO:0098839
GO:0098978
GO:0099557
GO:0140096
GO:1905608
HMNXSV003036717
ILMN_1695606
PH_hs_0031106
TC17000114.hg
U66406_at
g1469781_3p_a_at
g4503488_3p_at
Participates
as a member of
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
Other forms of this molecule
EFNB3 [plasma membrane]
Inferred To
phospho-Efnb3 [plasma membrane]
(Mus musculus)
phospho-Efnb3 [plasma membrane]
(Rattus norvegicus)
phospho-EFNB3 [plasma membrane]
(Bos taurus)
phospho-EFNB3 [plasma membrane]
(Canis familiaris)
phospho-EFNB3 [plasma membrane]
(Sus scrofa)
phospho-efnb3b [plasma membrane]
(Danio rerio)
phospho-efn-2 [plasma membrane]
(Caenorhabditis elegans)
phospho-efnb3 [plasma membrane]
(Xenopus tropicalis)
phospho-Ephrin [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O4'-phospho-L-tyrosine at 318
Coordinate
318
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 323
Coordinate
323
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 337
Coordinate
337
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENSG00000108947
,
ENSP00000226091
,
ENST00000226091
OpenTargets
ENSG00000108947
GeneCards
EFNB3
HPA
ENSG00000108947-EFNB3
PRO
Q15768
Pharos - Targets
Q15768
GlyGen
Q15768
PDB
4BKF
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54764 EPHA4
2
p-Y596,Y602-EPHA4 [plasma membrane]
(R-HSA-3928352)
EPHA4 [plasma membrane]
(R-HSA-2682325)
0.688
3
UniProt:O43502 RAD51C
1
RAD51C [nucleoplasm]
(R-HSA-217039)
0.527
2
UniProt:P32971 TNFSF8
1
TNFSF8 [plasma membrane]
(R-HSA-5667148)
0.527
2
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