Reactome | PTPN2 [cytosol]

PTPN2 [cytosol]

Stable Identifier

R-HSA-997292

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TC-PTPb, Tyrosine-protein phosphatase non-receptor type 2, PTN2_HUMAN, TC48

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17706 PTPN2

Gene Names

PTPN2, PTPT

Chain

chain:1-415

Reference Genes

ENSEMBL:ENSG00000175354 PTPN2

Participates

as a member of

PTPN1,PTPN2 [cytosol] (Homo sapiens)

as an input of

p-PKR dimer phosphorylates PTPN2 (Homo sapiens)

Other forms of this molecule

p-PTPN2 [cytosol]

PTPN2 [nucleoplasm]

Inferred To

PTPN2 [cytosol] (Bos taurus)

PTPN2 [cytosol] (Canis familiaris)

PTPN2 [cytosol] (Danio rerio)

PTPN2 [cytosol] (Drosophila melanogaster)

PTPN2 [cytosol] (Gallus gallus)

PTPN2 [cytosol] (Mus musculus)

PTPN2 [cytosol] (Rattus norvegicus)

PTPN2 [cytosol] (Sus scrofa)

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10912 GHR	7	GHR activated [plasma membrane] (R-HSA-1168385) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [endosome lumen] (R-HSA-1169263) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226)	0.645	8
UniProt:P20908 COL5A1	20	3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663)	0.589	2
UniProt:Q2GHU2 Q2GHU2			0.557	4
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:O43505 B4GAT1	1	B4GAT1 [Golgi membrane] (R-HSA-916821)	0.527	3
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:Q6ZMH5 SLC39A5	1	SLC39A5 [plasma membrane] (R-HSA-442360)	0.527	2
UniProt:P07306 ASGR1	1	PALM-C36-ASGR1 [plasma membrane] (R-HSA-8855714)	0.527	2
UniProt:P56199 ITGA1	1	ITGA1 [plasma membrane] (R-HSA-215939)	0.463	2

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