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Factor V precursor [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-5689447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Homo sapiens)
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
Factor V precursor [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12259 F5
Gene Names
F5
Chain
signal peptide:1-28, chain:29-2224, chain:29-737, propeptide:738-1573, chain:1574-2224
Reference Genes
BioGPS Gene:2153 F5
COSMIC (genes):F5 F5
CTD Gene:2153 F5
dbSNP Gene:2153 F5
ENSEMBL:ENSG00000198734 F5
ENSEMBL_homo_sapiens_GENE:ENSG00000198734.12 F5
HGNC:3542 F5
KEGG Gene (Homo sapiens):2153 F5
Monarch:2153 F5
NCBI Gene:2153 F5
OMIM:612309 F5
UCSC:P12259 F5
Reference Transcript
RefSeq:NM_000130.4 F5
Other Identifiers
11723553_at
11723554_at
11751042_a_at
11758395_s_at
16696187
204713_PM_s_at
204713_s_at
204714_PM_s_at
204714_s_at
2153
231029_PM_at
231029_at
2443369
2443371
2443372
2443373
2443374
2443375
2443377
2443378
2443381
2443382
2443383
2443384
2443385
2443386
2443388
2443389
2443391
2443392
2443393
2443394
2443395
2443396
2443397
2443398
2443399
2443400
2443402
2443403
2443404
2443405
2443406
2443407
2443408
2443410
2443412
2443413
2443414
2443415
35245_at
62710_at
7922174
A_23_P148768
A_32_P41604
GE57848
GO:0003013
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005886
GO:0007596
GO:0007599
GO:0008015
GO:0016020
GO:0030134
GO:0031091
GO:0031093
GO:0031410
GO:0032571
GO:0033116
GO:0042060
GO:0043226
GO:0046872
GO:1903561
HMNXSV003023557
Hs.165077.0.A1_3p_at
Hs.30054.0.S1_3p_a_at
ILMN_1709233
M16967_at
PH_hs_0002589
PH_hs_0020466
TC01003498.hg
g10518500_3p_a_at
Participates
as a member of
glycosylated FV, FVIII precursor [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
factor V [platelet alpha granule lumen]
F5(535-737) [extracellular region]
F5(335-534) [extracellular region]
F5(29-334) [extracellular region]
F5(29-534) [extracellular region]
factor V activation peptide [extracellular region]
factor V [extracellular region]
factor Va heavy chain [extracellular region]
factor Va light chain [extracellular region]
factor Va heavy chain [plasma membrane]
p-Factor V precursor [endoplasmic reticulum lumen]
Factor V precursor [COPII-coated ER to Golgi transport vesicle]
Factor V precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
factor Va light chain [plasma membrane]
Inferred To
f5 [endoplasmic reticulum lumen]
(Danio rerio)
F5 [endoplasmic reticulum lumen]
(Bos taurus)
F5 [endoplasmic reticulum lumen]
(Canis familiaris)
F5 [endoplasmic reticulum lumen]
(Sus scrofa)
Factor V precursor [endoplasmic reticulum lumen]
(Gallus gallus)
Factor V precursor [endoplasmic reticulum lumen]
(Mus musculus)
Cross References
RefSeq
NP_000121.2
Guide to Pharmacology - Targets
2606
OpenTargets
ENSG00000198734
ZINC - Substances
FA5_HUMAN
ZINC target
P12259
PRO
P12259
PDB
1CZV
,
8FDG
,
7TPP
,
8TN9
,
7TPQ
,
1CZS
,
7KXY
,
7KVE
,
3P70
,
3S9C
,
7KVF
,
1CZT
,
3P6Z
HPA
ENSG00000198734-F5
GeneCards
P12259
Ensembl
ENSG00000198734
,
ENST00000367797
,
ENSP00000356771
Pharos - Targets
P12259
ZINC - Predictions - Purchasable
FA5_HUMAN
Orphanet
16014
HMDB Protein
HMDBP02118
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78380 OLR1
3
OLR1 [tertiary granule membrane]
(R-HSA-6800883)
OLR1 [plasma membrane]
(R-HSA-203139)
OLR1 [specific granule membrane]
(R-HSA-6799518)
0.589
2
UniProt:P32971 TNFSF8
1
TNFSF8 [plasma membrane]
(R-HSA-5667148)
0.527
3
UniProt:Q13201 MMRN1
2
MMRN1(20-1228) [extracellular region]
(R-HSA-114635)
MMRN1(20-1228) [platelet alpha granule lumen]
(R-HSA-114634)
0.527
2
UniProt:A4D1S0 KLRG2
0.527
2
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