Reactome | factor Va light chain [plasma membrane]

factor Va light chain [plasma membrane]

Stable Identifier

R-HSA-140660

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

F5(1574-2224)

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
2827731	Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats Kane, WH, Ichinose, A, Davie, EW, Hagen, FS	Biochemistry	1987
3092220	Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin Kane, WH, Davie, EW	Proc Natl Acad Sci U S A	1986
12393635	Factor V: a combination of Dr Jekyll and Mr Hyde Kalafatis, M, Mann, KG	Blood	2003

External Reference Information

External Reference

UniProt:P12259 F5

Gene Names

Chain

signal peptide:1-28, chain:29-2224, chain:29-737, propeptide:738-1573, chain:1574-2224

Reference Genes

BioGPS Gene:2153 F5

COSMIC (genes):F5 F5

CTD Gene:2153 F5

dbSNP Gene:2153 F5

ENSEMBL:ENSG00000198734.12 F5

HGNC:3542 F5

KEGG Gene (Homo sapiens):2153 F5

Monarch:2153 F5

NCBI Gene:2153 F5

OMIM:612309 F5

UCSC:P12259 F5

Reference Transcript

RefSeq:NM_000130.4 F5

Other Identifiers

0006200270

11723553_at

11723554_at

11751042_a_at

11758395_s_at

16696187

204713_PM_s_at

204713_s_at

204714_PM_s_at

204714_s_at

2153

231029_PM_at

231029_at

2443369

2443371

2443372

2443373

2443374

2443375

2443377

2443378

2443381

2443382

2443383

2443384

2443385

2443386

2443388

2443389

2443391

2443392

2443393

2443394

2443395

2443396

2443397

2443398

2443399

2443400

2443402

2443403

2443404

2443405

2443406

2443407

2443408

2443410

2443412

2443413

2443414

2443415

35245_at

62710_at

7922174

A_23_P148768

A_32_P41604

GE57848

GO:0003013

GO:0005507

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005886

GO:0007596

GO:0007599

GO:0008015

GO:0016020

GO:0030134

GO:0031091

GO:0031093

GO:0031410

GO:0032571

GO:0033116

GO:0042060

GO:0043226

GO:0046872

GO:0050878

GO:1903561

HMNXSV003023557

Hs.165077.0.A1_3p_at

Hs.30054.0.S1_3p_a_at

ILMN_1709233

M16967_at

PH_hs_0002589

PH_hs_0020466

TC01003498.hg

g10518500_3p_a_at

Participates

as a component of

factor Va [plasma membrane] (Homo sapiens)

Other forms of this molecule

factor V [platelet alpha granule lumen]

F5(535-737) [extracellular region]

F5(335-534) [extracellular region]

F5(29-334) [extracellular region]

F5(29-534) [extracellular region]

Factor V precursor [endoplasmic reticulum lumen]

p-Factor V precursor [endoplasmic reticulum lumen]

Factor V precursor [COPII-coated ER to Golgi transport vesicle]

Factor V precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]

factor Va heavy chain [plasma membrane]

factor Va light chain [extracellular region]

factor Va heavy chain [extracellular region]

factor V [extracellular region]

factor V activation peptide [extracellular region]

Inferred To

F5 [plasma membrane] (Bos taurus)

F5 [plasma membrane] (Gallus gallus)

F5 [plasma membrane] (Sus scrofa)

f5 [plasma membrane] (Xenopus tropicalis)

factor Va light chain [plasma membrane] (Canis familiaris)

factor Va light chain [plasma membrane] (Danio rerio)

factor Va light chain [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_000121.2

Guide to Pharmacology - Targets

2606

OpenTargets

ENSG00000198734

ZINC - Substances

FA5_HUMAN

ZINC target

P12259

PRO

P12259

PDB

3S9C, 7KVE, 3P70, 1CZT, 7KXY, 3P6Z, 1CZS, 1CZV, 7KVF

HPA

ENSG00000198734-F5

GeneCards

P12259

Ensembl

ENSG00000198734, ENSP00000356771, ENST00000367797

Pharos - Targets

P12259

ZINC - Predictions - Purchasable

FA5_HUMAN

Orphanet

16014

HMDB Protein

HMDBP02118