Reactome | BMP10 [extracellular region]

BMP10 [extracellular region]

Stable Identifier

R-HSA-8858374

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Bone morphogenetic protein 10, BMP10_HUMAN, BMP10

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by BMP (Homo sapiens)
    - ACVRL1 binds BMP9,BMP10 (Homo sapiens)
      - ACVRL1:GDF2 dimer, BMP10 dimer [plasma membrane] (Homo sapiens)
        
        GDF2 dimer, BMP10 dimer [extracellular region] (Homo sapiens)
        
        BMP10 dimer [extracellular region] (Homo sapiens)
        
        BMP10 [extracellular region] (Homo sapiens)
      - GDF2 dimer, BMP10 dimer [extracellular region] (Homo sapiens)
        
        BMP10 dimer [extracellular region] (Homo sapiens)
        
        BMP10 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95393 BMP10

Gene Names

BMP10

Chain

signal peptide:1-21, propeptide:22-316, chain:317-424

Reference Genes

BioGPS Gene:27302 BMP10

COSMIC (genes):BMP10 BMP10

CTD Gene:27302 BMP10

dbSNP Gene:27302 BMP10

ENSEMBL:ENSG00000163217 BMP10

ENSEMBL_homo_sapiens_GENE:ENSG00000163217.2 BMP10

HGNC:20869 BMP10

KEGG Gene (Homo sapiens):27302 BMP10

Monarch:27302 BMP10

NCBI Gene:27302 BMP10

OMIM:608748 BMP10

UCSC:O95393 BMP10

Reference Transcript

RefSeq:NM_014482.2 BMP10

Other Identifiers

11738424_at

16898558

208292_PM_at

208292_at

2557938

2557940

2557941

2557943

2557945

2557947

2557949

2557950

2557951

2557952

27302

31399_at

50622_at

8052747

A_23_P131588

A_32_P83315

GE54794

GE563825

GO:0001822

GO:0003012

GO:0003013

GO:0005125

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0006351

GO:0006355

GO:0007010

GO:0007155

GO:0007507

GO:0007512

GO:0008083

GO:0008092

GO:0009986

GO:0010596

GO:0010613

GO:0010614

GO:0010628

GO:0023052

GO:0030018

GO:0030154

GO:0030308

GO:0030336

GO:0030509

GO:0031433

GO:0032924

GO:0033612

GO:0043226

GO:0045214

GO:0045893

GO:0048018

GO:0048856

GO:0048870

GO:0055009

GO:0055010

GO:0055015

GO:0055117

GO:0060038

GO:0060045

GO:0060298

GO:0060347

GO:0060391

GO:0061036

GO:0098772

GO:1903242

GO:2000138

HMNXSV003006366

ILMN_1791688

PH_hs_0009590

TC02001945.hg

g7656927_3p_at

Participates

as a component of

BMP10 dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

BMP10(22-424) [extracellular region]

Inferred To

Homologues of BMP10 [extracellular region] (Drosophila melanogaster)

mav [extracellular region] (Drosophila melanogaster)

BMP10 [extracellular region] (Bos taurus)

BMP10 [extracellular region] (Canis familiaris)

BMP10 [extracellular region] (Gallus gallus)

BMP10 [extracellular region] (Sus scrofa)

Bmp10 [extracellular region] (Mus musculus)

Bmp10 [extracellular region] (Rattus norvegicus)

bmp10 [extracellular region] (Xenopus tropicalis)

dpp [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_055297.1

OpenTargets

ENSG00000163217

HPA

ENSG00000163217-BMP10

GeneCards

O95393

Ensembl

ENST00000295379, ENSP00000295379, ENSG00000163217

PRO

O95393

Pharos - Targets

O95393

PDB

7PPA, 7PPC, 7PPB, 6SF1, 6SF3

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:P43629 KIR3DL1	1	KIR3DL1 [plasma membrane] (R-HSA-197742)	0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:Q6Q788 APOA5	4	APOA5 [endoplasmic reticulum lumen] (R-HSA-8956716) p-APOA5 [endoplasmic reticulum lumen] (R-HSA-8956979) APOA5 [extracellular region] (R-HSA-174608) APOA5 [cytosol] (R-HSA-6784664)	0.556	3
UniProt:P26951 IL3RA	1	IL3RA [plasma membrane] (R-HSA-879938)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636) GJB1 [endoplasmic reticulum membrane] (R-HSA-190656)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3

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