Reactome | CXCL9 [extracellular region]

CXCL9 [extracellular region]

Stable Identifier

R-HSA-373856

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C-X-C motif chemokine 9, CXCL9_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL9 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07325 CXCL9

Gene Names

CXCL9, CMK, MIG, SCYB9

Chain

signal peptide:1-22, chain:23-125

Reference Genes

BioGPS Gene:4283 CXCL9

COSMIC (genes):CXCL9 CXCL9

CTD Gene:4283 CXCL9

dbSNP Gene:4283 CXCL9

ENSEMBL:ENSG00000138755 CXCL9

HGNC:7098 CXCL9

KEGG:hsa:4283 CXCL9

Monarch:4283 CXCL9

NCBI Gene:4283 CXCL9

OMIM:601704 CXCL9

UCSC:Q07325 CXCL9

Reference Transcript

RefSeq:NM_002416.2 CXCL9

Other Identifiers

11719943_at

16977045

203915_PM_at

203915_at

2773946

2773948

2773949

2773950

2773951

2773952

2773953

2773954

37219_at

4283

8101118

A_23_P18452

GE59980

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0006968

GO:0007165

GO:0007186

GO:0007189

GO:0007267

GO:0008009

GO:0009617

GO:0009897

GO:0023052

GO:0030593

GO:0042127

GO:0045236

GO:0045663

GO:0048018

GO:0048248

GO:0048870

GO:0051281

GO:0051607

GO:0061844

GO:0070098

GO:0071222

GO:0098542

GO:0098772

GO:1901741

HMNXSV003054656

ILMN_1745356

PH_hs_0004459

TC04001304.hg

X72755_at

g4505186_3p_at

Participates

as a member of

CXCR3 ligands [extracellular region] (Homo sapiens)

Inferred To

Homologues of CXCL9 [extracellular region] (Danio rerio)

Homologues of CXCL9 [extracellular region] (Gallus gallus)

cxcl8b.1 [extracellular region] (Danio rerio)

k60 [extracellular region] (Gallus gallus)

CXCL8 [extracellular region] (Gallus gallus)

CXCL9 [extracellular region] (Bos taurus)

CXCL9 [extracellular region] (Gallus gallus)

CXCL9 [extracellular region] (Sus scrofa)

cxcl8b.3 [extracellular region] (Danio rerio)

Cxcl9 [extracellular region] (Mus musculus)

Cxcl9 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_002407.1

ENSEMBL

ENSP00000354901, ENST00000264888, ENSG00000138755

OpenTargets

ENSG00000138755

GeneCards

CXCL9

HPA

ENSG00000138755-CXCL9

PRO

Q07325

Pharos - Targets

Q07325

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.781	7
UniProt:P27487 DPP4	2	DPP4(1-766) [plasma membrane] (R-HSA-400527) DPP4(39-766) [extracellular region] (R-HSA-400517)	0.623	2
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	2
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	2
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum membrane] (R-HSA-190656) GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636)	0.556	3
UniProt:Q9UN42 ATP1B4	1	ATP1B4 [nuclear envelope] (R-HSA-939761)	0.556	3
UniProt:Q9Y3A6 TMED5	1	TMED5 [endoplasmic reticulum membrane] (R-HSA-3247761)	0.556	3
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:Q9UBD6 RHCG	1	RHCG [plasma membrane] (R-HSA-444397)	0.556	3