Reactome | p-Y151-WASF1 [cytosol]

p-Y151-WASF1 [cytosol]

Stable Identifier

R-HSA-2029058

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-151Y-WAVE1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
      - ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        p-Y-WRC [cytosol] (Homo sapiens)
        
        p-Y-WAVE [cytosol] (Homo sapiens)
        
        p-Y151-WASF1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92558 WASF1

Gene Names

WASF1, KIAA0269, SCAR1, WAVE1

Chain

chain:1-559

Reference Genes

BioGPS Gene:8936 WASF1

COSMIC (genes):WASF1 WASF1

CTD Gene:8936 WASF1

dbSNP Gene:8936 WASF1

ENSEMBL:ENSG00000112290 WASF1

HGNC:12732 WASF1

KEGG:hsa:8936 WASF1

Monarch:8936 WASF1

NCBI Gene:8936 WASF1

OMIM:605035 WASF1

UCSC:Q92558 WASF1

Reference Transcript

Other Identifiers

11723005_a_at

11731581_a_at

11731582_a_at

17022529

204165_PM_at

204165_at

2969296

2969297

2969299

2969300

2969301

2969302

2969304

2969305

2969306

2969307

2969308

2969309

2969310

2969311

2969312

2969313

2969319

2969320

2969323

2969325

2969327

2969328

37190_at

8128818

8936

A_23_P168306

A_33_P3243812

D87459_at

GE57411

GO:0003779

GO:0005515

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0005856

GO:0005925

GO:0006898

GO:0007005

GO:0007010

GO:0008092

GO:0015629

GO:0016192

GO:0016601

GO:0030027

GO:0030036

GO:0030041

GO:0031175

GO:0031209

GO:0031267

GO:0032991

GO:0034237

GO:0034330

GO:0043226

GO:0045202

GO:0051018

GO:0051388

GO:0065003

GO:0070161

GO:0071933

GO:0072673

GO:0097484

GO:0098794

GO:0098885

GO:1990416

GO:2000601

HMNXSV003000290

ILMN_1756079

ILMN_2342174

PH_hs_0027688

TC06002007.hg

g4507912_3p_at

Participates

as a candidate of

p-Y-WAVE [cytosol] (Homo sapiens)

Other forms of this molecule

WASF1 [cytosol]

p-Y151,S,T-WASF1 [cytosol]

Inferred To

phospho-SCAR [cytosol] (Drosophila melanogaster)

phospho-gukh [cytosol] (Drosophila melanogaster)

phospho-WASF1 [cytosol] (Bos taurus)

phospho-WASF1 [cytosol] (Canis familiaris)

phospho-p-Y151-WASF1 [cytosol] (Gallus gallus)

phospho-p-Y151-WASF1 [cytosol] (Sus scrofa)

phospho-Wasf1 [cytosol] (Mus musculus)

phospho-Wasf1 [cytosol] (Rattus norvegicus)

phospho-wve-1 [cytosol] (Caenorhabditis elegans)

phospho-scrA [cytosol] (Dictyostelium discoideum)

Homologues of p-Y151-WASF1 [cytosol] (Drosophila melanogaster)

phospho-wasf1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 151

Coordinate

151

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003922.1, NP_001020105.1, XP_005267264.1, XP_005267262.1, XP_005267263.1, XP_016866927.1, XP_005267260.1, XP_016866926.1, XP_011534536.1, NP_001020107.1, NP_001020106.1, XP_011534535.1

OpenTargets

ENSG00000112290

ENSEMBL

ENSP00000376368, ENSP00000376366, ENST00000392586, ENSP00000376365, ENSP00000376367, ENST00000359451, ENSP00000352425, ENST00000392588, ENST00000392587, ENST00000392589

HPA

ENSG00000112290-WASF1

PRO

Q92558

Pharos - Targets

Q92558

GlyGen

Q92558

PDB

4N78, 7USC, 3P8C, 7USD, 7USE

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.742	5
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.659	3
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.641	3
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.571	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q8IY31 IFT20	3	IFT20 [ciliary tip] (R-HSA-5625355) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [cilium] (R-HSA-5617624)	0.488	2

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