Reactome | p-4S-ABI2 [cytosol]

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p-4S-ABI2

Stable Identifier

R-HSA-2029003

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-ABI2, Abl interactor 2

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases (Homo sapiens)
  - RHO GTPase Effectors (Homo sapiens)
    - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
      - Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYB9 ABI2

Gene Names

ABI2, ARGBPIA

Chain

chain:1-513

Reference Genes

BioGPS Gene:10152 ABI2

COSMIC (genes):ABI2 ABI2

CTD Gene:10152 ABI2

dbSNP Gene:10152 ABI2

ENSEMBL:ENSG00000138443 ABI2

HGNC:24011 ABI2

KEGG Gene (Homo sapiens):hsa:10152 ABI2

Monarch:10152 ABI2

NCBI Gene:10152 ABI2

OMIM:606442 ABI2

UCSC:Q9NYB9 ABI2

Reference Transcript

Other Identifiers

10152

1040_s_at

11727019_at

11727020_at

11727021_a_at

11746841_a_at

11746842_x_at

11746843_a_at

11751403_a_at

11751404_x_at

11760619_x_at

134_at

135_g_at

16889779

207268_x_at

209856_x_at

211793_s_at

225098_at

225112_at

2523690

2523691

2523692

2523703

2523704

2523705

2523710

2523716

2523718

2523720

2523725

2523728

2523729

2523730

2523731

2523733

2523734

2523735

2523736

2523737

2523738

2523739

2523740

2523741

2523742

36448_at

44746_at

52796_at

65721_at

8047659

A_23_P79692

A_24_P933418

ABI2

ABI2-202

B7Z836

CCDS2358

ENSG00000138443

ENSP00000261017

ENST00000261017

EntrezGene:10152

g7839523_3p_a_at

GE81557

GE85898

GO:0003677

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0006928

GO:0007010

GO:0008093

GO:0008154

GO:0016032

GO:0016477

GO:0016601

GO:0017124

GO:0018108

GO:0019900

GO:0030027

GO:0030175

GO:0030296

GO:0031209

GO:0031625

GO:0032403

GO:0042995

GO:0048365

GO:0061098

GO:0070064

GO:2000601

HGNC:24011

Hs.285728.0.A1_3p_at

Hs.285728.0.A2_3p_at

Hs.471156

ILMN_1720988

ILMN_1724497

ILMN_1775944

NM_005759

NP_005750

PF07815

PF14604

PH_hs_0024439

SM00326

TC02001198.hg

U23435_s_at

uc002uzz.5

UPI0000070712

X95632_s_at

X95677_at

XM_005246218

XM_005246226

XM_006712180

XM_017003124

XM_017003125

XM_017003126

XM_017003127

XM_017003134

XM_017003135

XM_017003136

XM_017003137

XM_017003138

XM_017003139

XM_017003140

XM_017003141

XM_017003142

XP_005246275

XP_005246283

XP_006712243

XP_016858613

XP_016858614

XP_016858615

XP_016858616

XP_016858623

XP_016858624

XP_016858625

XP_016858626

XP_016858627

XP_016858628

XP_016858629

XP_016858630

XP_016858631

Participant Of

hasCandidate

p-ABI [cytosol]

Other forms of this molecule

ABI2 [cytosol]

Inferred To

phospho-p-4S-ABI2 [cytosol] (Bos taurus)

phospho-p-4S-ABI2 [cytosol] (Caenorhabditis elegans)

phospho-p-4S-ABI2 [cytosol] (Canis familiaris)

phospho-p-4S-ABI2 [cytosol] (Danio rerio)

phospho-p-4S-ABI2 [cytosol] (Drosophila melanogaster)

phospho-p-4S-ABI2 [cytosol] (Gallus gallus)

phospho-p-4S-ABI2 [cytosol] (Mus musculus)

phospho-p-4S-ABI2 [cytosol] (Rattus norvegicus)

phospho-p-4S-ABI2 [cytosol] (Sus scrofa)

phospho-p-4S-ABI2 [cytosol] (Taeniopygia guttata)

phospho-p-4S-ABI2 [cytosol] (Xenopus tropicalis)

Homologues of p-4S-ABI2 [cytosol] (Canis familiaris)

Homologues of p-4S-ABI2 [cytosol] (Danio rerio)

Homologues of p-4S-ABI2 [cytosol] (Drosophila melanogaster)

Homologues of p-4S-ABI2 [cytosol] (Sus scrofa)

Homologues of p-4S-ABI2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 183

Coordinate

183

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 225

Coordinate

225

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 410

Coordinate

410

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 216

Coordinate

216

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001269854.1, NP_005750.4, XP_006712248.1, NP_001269856.1, NP_001269855.1

GeneCards

Q9NYB9

DOCK Blaster

3P8C, 4N78

PRO

Q9NYB9

PDB

2ED0, 3P8C, 4N78

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IY31 IFT20	3	IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [cilium] (R-HSA-5617624) IFT20 [ciliary tip] (R-HSA-5625355)	0.666	4
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.666	4
UniProt:Q08117 AES	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.556	3
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.556	3
UniProt:P50552 VASP	2	VASP [cytosol] (R-HSA-446323) VASP [cytosol] (R-HSA-426404)	0.556	3
UniProt:O14964 HGS	1	HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:Q13526 PIN1	1	PIN1 [nucleoplasm] (R-HSA-936016)	0.556	3
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.556	3
UniProt:P00519 ABL1	5	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [cytosol] (R-HSA-375987) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251)	0.524	2