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ABI2 [cytosol]
Stable Identifier
R-HSA-1671647
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Abl interactor 2, ABI2_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 binds effectors at the plasma membrane (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE1 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE1 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYB9 ABI2
Gene Names
ABI2, ARGBPIA
Chain
chain:1-513
Reference Genes
BioGPS Gene:10152 ABI2
COSMIC (genes):ABI2 ABI2
CTD Gene:10152 ABI2
dbSNP Gene:10152 ABI2
ENSEMBL:ENSG00000138443 ABI2
HGNC:24011 ABI2
KEGG:hsa:10152 ABI2
Monarch:10152 ABI2
NCBI Gene:10152 ABI2
OMIM:606442 ABI2
UCSC:Q9NYB9 ABI2
Reference Transcript
RefSeq:NM_001282925.1 ABI2
RefSeq:NM_001282927.1 ABI2
RefSeq:NM_005759.5 ABI2
RefSeq:NM_001282926.1 ABI2
RefSeq:XM_006712185.1 ABI2
Participates
as a candidate of
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
Other forms of this molecule
p-4S-ABI2 [cytosol]
Inferred To
abi-1 [cytosol]
(Caenorhabditis elegans)
ABI2 [cytosol]
(Bos taurus)
ABI2 [cytosol]
(Canis familiaris)
ABI2 [cytosol]
(Gallus gallus)
ABI2 [cytosol]
(Sus scrofa)
abi2 [cytosol]
(Xenopus tropicalis)
Abi [cytosol]
(Drosophila melanogaster)
abiA [cytosol]
(Dictyostelium discoideum)
Abi2 [cytosol]
(Mus musculus)
Abi2 [cytosol]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000138443
ENSEMBL
ENSG00000138443
,
ENSP00000261017
,
ENST00000261017
HPA
ENSG00000138443-ABI2
GeneCards
ABI2
PRO
Q9NYB9
Pharos - Targets
Q9NYB9
GlyGen
Q9NYB9
PDB
3P8C
,
2ED0
,
4N78
,
7USD
,
7USE
,
7USC
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.801
8
UniProt:Q8IY31 IFT20
3
IFT20 [cilium]
(R-HSA-5617624)
IFT20 [Golgi membrane]
(R-HSA-5617625)
IFT20 [ciliary tip]
(R-HSA-5625355)
0.742
6
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.742
6
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.666
5
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.666
5
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.666
5
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.666
6
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.666
5
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.666
5
UniProt:Q9UL45 BLOC1S6
1
BLOC1S6 [cytosol]
(R-HSA-429816)
0.666
5
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.666
5
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.643
3
UniProt:P00519 ABL1
6
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
0.641
3
UniProt:P18206 VCL
8
VCL [cytosol]
(R-HSA-350753)
VCL [ficolin-1-rich granule lumen]
(R-HSA-6800985)
VCL [extracellular region]
(R-HSA-350736)
VCL [secretory granule lumen]
(R-HSA-6801010)
VCL [specific granule lumen]
(R-HSA-6799711)
VCL(95 kDa) [cytosol]
(R-HSA-9861471)
VCL(1-811)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713480)
VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713472)
0.553
3
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.527
2
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