Reactome | WASF1 [cytosol]

WASF1 [cytosol]

Stable Identifier

R-HSA-200965

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Wave1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF1 [cytosol] (Homo sapiens)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF1 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92558 WASF1

Gene Names

WASF1, KIAA0269, SCAR1, WAVE1

Chain

chain:1-559

Reference Genes

BioGPS Gene:8936 WASF1

COSMIC (genes):WASF1 WASF1

CTD Gene:8936 WASF1

dbSNP Gene:8936 WASF1

ENSEMBL:ENSG00000112290 WASF1

ENSEMBL_homo_sapiens_GENE:ENSG00000112290.13 WASF1

HGNC:12732 WASF1

KEGG Gene (Homo sapiens):8936 WASF1

Monarch:8936 WASF1

NCBI Gene:8936 WASF1

OMIM:605035 WASF1

UCSC:Q92558 WASF1

Reference Transcript

Other Identifiers

11723005_a_at

11731581_a_at

11731582_a_at

17022529

204165_PM_at

204165_at

2969296

2969297

2969299

2969300

2969301

2969302

2969304

2969305

2969306

2969307

2969309

2969310

2969311

2969312

2969313

2969319

2969320

2969325

2969327

2969328

37190_at

8128818

8936

A_23_P168306

A_33_P3243812

D87459_at

GE57411

GO:0003779

GO:0005515

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0005856

GO:0005925

GO:0006898

GO:0007005

GO:0007010

GO:0008092

GO:0015629

GO:0016192

GO:0016601

GO:0023052

GO:0030027

GO:0030036

GO:0030041

GO:0030154

GO:0031175

GO:0031209

GO:0031267

GO:0032991

GO:0034237

GO:0034330

GO:0043226

GO:0045202

GO:0048856

GO:0051018

GO:0051388

GO:0065003

GO:0070161

GO:0071933

GO:0072673

GO:0097484

GO:0098794

GO:0098885

GO:1990416

GO:2000601

HMNXSV003000290

ILMN_1756079

ILMN_2342174

PH_hs_0027688

TC06002007.hg

g4507912_3p_at

Participates

as a component of

WAVE1 Regulatory Complex [cytosol] (Homo sapiens)

as a candidate of

WAVEs [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y151,S,T-WASF1 [cytosol]

p-Y151-WASF1 [cytosol]

Inferred To

SCAR [cytosol] (Drosophila melanogaster)

Homologues of WASF1 [cytosol] (Drosophila melanogaster)

wasf1 [cytosol] (Xenopus tropicalis)

wve-1 [cytosol] (Caenorhabditis elegans)

gukh [cytosol] (Drosophila melanogaster)

Wasf1 [cytosol] (Mus musculus)

Wasf1 [cytosol] (Rattus norvegicus)

scrA [cytosol] (Dictyostelium discoideum)

WASF1 [cytosol] (Bos taurus)

WASF1 [cytosol] (Canis familiaris)

WASF1 [cytosol] (Gallus gallus)

WASF1 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016866927.1, XP_005267264.1, XP_005267260.1, XP_005267262.1, XP_011534536.1, NP_001020107.1, NP_001020105.1, XP_016866926.1, XP_005267263.1, NP_001020106.1, NP_003922.1, XP_011534535.1

OpenTargets

ENSG00000112290

GeneCards

Q92558

HPA

ENSG00000112290-WASF1

Ensembl

ENSP00000376367, ENST00000392586, ENSP00000376365, ENSP00000376368, ENSP00000352425, ENST00000392589, ENST00000392587, ENST00000392588, ENST00000359451, ENSG00000112290, ENSP00000376366

PRO

Q92558

Pharos - Targets

Q92558

PDB

7USD, 4N78, 3P8C, 7USE, 7USC

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.742	5
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.659	3
UniProt:P07737 PFN1	2	PFN1 [cytosol] (R-HSA-203081) PFN1 [extracellular region] (R-HSA-350755)	0.641	3
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.571	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q8IY31 IFT20	3	IFT20 [cilium] (R-HSA-5617624) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [ciliary tip] (R-HSA-5625355)	0.488	2