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Mitochondrial tRNA aminoacylation
Stable Identifier
R-HSA-379726
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Mitochondrial tRNA aminoacylation (Homo sapiens)
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Mitochondrial tRNA synthetases act in the mitochondrial matrix to catalyze the reactions of tRNAs encoded in the mitochondrial genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate (Schneider et al. 2000). The synthetase enzymes that catalyze these reactions are all encoded in the nuclear genome. In three cases, glycine, lysine, and glutamine, a single gene encodes two enzyme isoforms, one cytosolic and one mitochondrial. All other mitochondrial tRNA synthetases are encoded by genes different from the ones encoding the corresponding cytosolic enzymes.
Literature References
PubMed ID
Title
Journal
Year
11121736
Mitochondrial tRNA import: are there distinct mechanisms?
Schneider, A
,
Marechal-Drouard, L
Trends Cell Biol
2000
Participants
Events
alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
(Homo sapiens)
arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate
(Homo sapiens)
asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
(Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
(Homo sapiens)
cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate
(Homo sapiens)
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
(Homo sapiens)
glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
(Homo sapiens)
glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
(Homo sapiens)
histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate
(Homo sapiens)
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
(Homo sapiens)
leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
(Homo sapiens)
lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
(Homo sapiens)
methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
(Homo sapiens)
phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
(Homo sapiens)
proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
(Homo sapiens)
serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
(Homo sapiens)
threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate
(Homo sapiens)
tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
(Homo sapiens)
tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate
(Homo sapiens)
valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
(Homo sapiens)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial]
(Homo sapiens)
Participates
as an event of
tRNA Aminoacylation (Homo sapiens)
Event Information
Go Biological Process
tRNA aminoacylation for protein translation (0006418)
Orthologous Events
Mitochondrial tRNA aminoacylation (Bos taurus)
Mitochondrial tRNA aminoacylation (Caenorhabditis elegans)
Mitochondrial tRNA aminoacylation (Canis familiaris)
Mitochondrial tRNA aminoacylation (Danio rerio)
Mitochondrial tRNA aminoacylation (Dictyostelium discoideum)
Mitochondrial tRNA aminoacylation (Drosophila melanogaster)
Mitochondrial tRNA aminoacylation (Gallus gallus)
Mitochondrial tRNA aminoacylation (Mus musculus)
Mitochondrial tRNA aminoacylation (Plasmodium falciparum)
Mitochondrial tRNA aminoacylation (Rattus norvegicus)
Mitochondrial tRNA aminoacylation (Saccharomyces cerevisiae)
Mitochondrial tRNA aminoacylation (Schizosaccharomyces pombe)
Mitochondrial tRNA aminoacylation (Sus scrofa)
Authored
D'Eustachio, P (2008-11-29)
Reviewed
Antonellis, A (2008-12-02)
Created
D'Eustachio, P (2008-11-05)
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