Reactome | proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate

proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate

Stable Identifier

R-HSA-380198

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PARS2 (mitochondrial prolyl tRNA synthetase) catalyzes the reaction of proline, mitochondrial tRNA(Pro), and ATP to form Pro-tRNA(Pro), AMP, and pyrophosphate. The PARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).

Participants

Input