tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate

Stable Identifier
R-HSA-380222
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
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WARS2 (mitochondrial tryptophanyl tRNA synthetase) catalyzes the reaction of tryptophan, mitochondrial tRNA(Trp), and ATP to form Trp-tRNA(Trp), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Jorgensen et al. 2000).
Literature References
PubMed ID Title Journal Year
10828066 Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase

Jorgensen, R, Sogaard, TM, Rossing, AB, Martensen, PM, Justesen, J

J Biol Chem 2000
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Catalyst Activity

tryptophan-tRNA ligase activity of WARS2 [mitochondrial matrix]

Physical Entity
WARS2 [mitochondrial matrix] (Homo sapiens)
Activity
tryptophan-tRNA ligase activity (GO:0004830)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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