leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate

Stable Identifier
R-HSA-380200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
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LARS2 (mitochondrial leucyl tRNA synthetase) catalyzes the reaction of leucine, mitochondrial tRNA(Leu), and ATP to form Leu-tRNA(Leu), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a monomer (Bullard et al. 2000).
Literature References
PubMed ID Title Journal Year
10684970 Expression and characterization of the human mitochondrial leucyl-tRNA synthetase

Spremulli, LL, Cai, YC, Bullard, JM

Biochim Biophys Acta 2000
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Catalyst Activity

leucine-tRNA ligase activity of LARS2(1-?) [mitochondrial matrix]

Physical Entity
LARS2(1-?) [mitochondrial matrix] (Homo sapiens)
Activity
leucine-tRNA ligase activity (GO:0004823)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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