phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate

Stable Identifier
R-HSA-380203
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
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FARS2 (mitochondrial phenylalanyl tRNA synthetase) catalyzes the reaction of phenylalanine, mitochondrial tRNA(Phe), and ATP to form Phe-tRNA(Phe), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a monomer (Bullard et al. 1999).
Literature References
PubMed ID Title Journal Year
10329163 Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase

Bullard, JM, Cai, YC, Demeler, B, Spremulli, LL

J Mol Biol 1999
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Catalyst Activity

phenylalanine-tRNA ligase activity of FARS2(1-?) [mitochondrial matrix]

Physical Entity
FARS2(1-?) [mitochondrial matrix] (Homo sapiens)
Activity
phenylalanine-tRNA ligase activity (GO:0004826)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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