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valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
Stable Identifier
R-HSA-380199
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Mitochondrial tRNA aminoacylation (Homo sapiens)
valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
VARS2 (mitochondrial valyl tRNA synthetase) catalyzes the reaction of valine, mitochondrial tRNA(val), and ATP to form Val-tRNA(Val), AMP, and pyrophosphate. The VARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
Participants
Input
ATP [mitochondrial matrix]
L-Val [mitochondrial matrix]
tRNA(Val) [mitochondrial matrix]
(Homo sapiens)
Output
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
Val-tRNA(Val) [mitochondrial matrix]
(Homo sapiens)
Participates
as an event of
Mitochondrial tRNA aminoacylation (Homo sapiens)
Catalyst Activity
valine-tRNA ligase activity of VARS2 [mitochondrial matrix]
Physical Entity
VARS2 [mitochondrial matrix]
(Homo sapiens)
Activity
valine-tRNA ligase activity (GO:0004832)
Inferred From
tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
Authored
D'Eustachio, P (2008-11-29)
Reviewed
Antonellis, A (2008-12-02)
Created
D'Eustachio, P (2008-11-08)
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