KARS (mitochondrial lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).
Schimmel, P, Stello, T, Motegi, H, Shiba, K, Musier-Forsyth, K, Noda, T
lysine-tRNA ligase activity of KARS dimer [mitochondrial matrix]
© 2022 Reactome