KARS (mitochondrial lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).
Shiba, K, Stello, T, Motegi, H, Noda, T, Musier-Forsyth, K, Schimmel, P
lysine-tRNA ligase activity of KARS dimer [mitochondrial matrix]
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