lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate

Stable Identifier
R-HSA-380233
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
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KARS (mitochondrial lysyl tRNA synthetase) catalyzes the reaction of lysine, tRNA(Lys), and ATP to form Lys-tRNA(Lys), AMP, and pyrophosphate. The enzyme, a class II tRNA synthetase, is a homodimer. The same gene encodes both cytosolic and mitochondrial KARS enzymes (Shiba et al. 1997).

Literature References
PubMed ID Title Journal Year
9278442 Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant

Shiba, K, Stello, T, Motegi, H, Noda, T, Musier-Forsyth, K, Schimmel, P

J Biol Chem 1997
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
lysine-tRNA ligase activity of KARS dimer [mitochondrial matrix]
Physical Entity
KARS dimer [mitochondrial matrix]
Activity
lysine-tRNA ligase activity (0004824)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)