glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate

Stable Identifier
R-HSA-380241
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
QARS (mitochondrial glutaminyl tRNA synthetase) catalyzes the reaction of glutamine, tRNA(Gln), and ATP to form Gln-tRNA(Gln), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase. The same gene encodes both the cytosolic and mitochondrial QARS enzymes (Lamour et al. 1994).
Literature References
PubMed ID Title Journal Year
8078941 Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer

Mirande, M, Quevillon, S, N'Guyen, VC, Lamour, V, Lipinski, M, Diriong, S

Proc Natl Acad Sci U S A 1994
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Catalyst Activity

glutamine-tRNA ligase activity of QARS [mitochondrial matrix]

Physical Entity
QARS [mitochondrial matrix] (Homo sapiens)
Activity
glutamine-tRNA ligase activity (GO:0004819)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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