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threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate
Stable Identifier
R-HSA-380201
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Mitochondrial tRNA aminoacylation (Homo sapiens)
threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TARS2 (mitochondrial threonyl tRNA synthetase) catalyzes the reaction of threonine, mitochondrial tRNA(Thr), and ATP to form Thr-tRNA(Thr), AMP, and pyrophosphate. The TARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).
Participants
Input
ATP [mitochondrial matrix]
L-Thr [mitochondrial matrix]
tRNA(Thr) [mitochondrial matrix]
(Homo sapiens)
Output
AMP [mitochondrial matrix]
PPi [mitochondrial matrix]
Thr-tRNA(Thr) [mitochondrial matrix]
(Homo sapiens)
Participates
as an event of
Mitochondrial tRNA aminoacylation (Homo sapiens)
Catalyst Activity
threonine-tRNA ligase activity of TARS2(1-?) [mitochondrial matrix]
Physical Entity
TARS2(1-?) [mitochondrial matrix]
(Homo sapiens)
Activity
threonine-tRNA ligase activity (GO:0004829)
Inferred From
tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
Authored
D'Eustachio, P (2008-11-29)
Reviewed
Antonellis, A (2008-12-02)
Created
D'Eustachio, P (2008-11-08)
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