isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate

Stable Identifier
R-HSA-380176
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
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IARS2 (mitochondrial isoleucyl tRNA synthetase) catalyzes the reaction of isoleucine, mitochondrial tRNA(Ile), and ATP to form Ile-tRNA(Ile), AMP, and pyrophosphate. The enzyme is a class I tRNA synthetase (Degoul et al. 1995).
Literature References
PubMed ID Title Journal Year
9466989 Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene

Florentz, C, Giege, R, Helm, M, Marsac, C, Leroux, J, Degoul, F, Cepanec, C, Brule, H

Hum Mol Genet 1998
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Catalyst Activity

isoleucine-tRNA ligase activity of IARS2 [mitochondrial matrix]

Physical Entity
IARS2 [mitochondrial matrix] (Homo sapiens)
Activity
isoleucine-tRNA ligase activity (GO:0004822)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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