Reactome | tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate

tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate

Stable Identifier

R-HSA-380170

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate

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YARS2 (mitochondrial tyrosyl tRNA synthetase) catalyzes the reaction of tyrosine, mitochondrial tRNA(Tyr), and ATP to form Tyr-tRNA(Tyr), AMP, and pyrophosphate. The enzyme, a class I tRNA synthetase, is a homodimer (Bonnefond et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15779907	Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS Florentz, C, Giege, R, Fender, A, Bonnefond, L, Sissler, M, Rudinger-Thirion, J	Biochemistry	2005