pyrophosphate + H2O => 2 orthophosphate [mitochondrial]

Stable Identifier
R-HSA-449937
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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pyrophosphate + H2O => 2 orthophosphate [mitochondrial]
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Mitochondrial PPA2 (pyrophosphatase (inorganic) 2) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme requires Mg++ for activity (Curbo et al. 2006). The enzyme is inferred to be a homodimer by analogy to its cytosolic isoform.
Literature References
PubMed ID Title Journal Year
16300924 Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes

Curbo, S, Lagier-Tourenne, C, Carrozzo, R, Palenzuela, L, Lucioli, S, Hirano, M, Santorelli, F, Arenas, J, Karlsson, A, Johansson, M

Genomics 2006
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Catalyst Activity

inorganic diphosphate phosphatase activity of PPA2 dimer [mitochondrial matrix]

Physical Entity
PPA2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
inorganic diphosphate phosphatase activity (GO:0004427)
This event is regulated
Requirements
Orthologous Events
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Gallus gallus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Plasmodium falciparum)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Rattus norvegicus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Schizosaccharomyces pombe)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Sus scrofa)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-12-10)
Reviewed
Jassal, B  (2010-02-27)
Created
D'Eustachio, P  (2009-12-10)
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