serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate

Stable Identifier
R-HSA-380239
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
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SARS2 (mitochondrial seryl tRNA synthetase) catalyzes the reaction of serine, mitochondrial tRNA(Ser), and ATP to form Ser-tRNA(Ser), AMP, and pyrophosphate. SARS2 is a class II tRNA synthetase inferred from the biochemical properties of its bovine homologue to function as a dimer (Yokogawa et al. 2000).
Literature References
PubMed ID Title Journal Year
10764807 Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase

Yokogawa, T, Shimada, N, Takeuchi, N, Benkowski, L, Suzuki, T, Omori, A, Ueda, T, Nishikawa, K, Spremulli, LL, Watanabe, K

J Biol Chem 2000
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Catalyst Activity

serine-tRNA ligase activity of SARS2 dimer [mitochondrial matrix]

Physical Entity
SARS2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
serine-tRNA ligase activity (GO:0004828)
Authored
D'Eustachio, P  (2008-11-29)
Reviewed
Antonellis, A  (2008-12-02)
Created
D'Eustachio, P  (2008-11-08)
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