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Downstream signal transduction
Stable Identifier
R-HSA-186763
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
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The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.
Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.
Literature References
PubMed ID
Title
Journal
Year
10508235
Mechanism of action and in vivo role of platelet-derived growth factor
Westermark, B
,
Heldin, CH
Physiol Rev
1999
9739761
Signal transduction via platelet-derived growth factor receptors
Ostman, A
,
Heldin, CH
,
Rönnstrand, L
Biochim Biophys Acta
1998
Participants
Events
PI3-kinase binds to the active receptor
(Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3
(Homo sapiens)
PLC-gamma binds to the active receptor
(Homo sapiens)
Phosphorylation of PLCgamma by PDGFR
(Homo sapiens)
Activated PLC gamma dissociates from the PDGF receptor
(Homo sapiens)
SH2 domain of Src binds to the active receptor
(Homo sapiens)
Activation of Src
(Homo sapiens)
SHP2 binds to the active receptor
(Homo sapiens)
GAP binds to PDGF-beta receptors only
(Homo sapiens)
GRB2:SOS1 complex binds to the active receptor
(Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
(Homo sapiens)
STAT binds to the active receptor
(Homo sapiens)
Crk binds to the active PDGF receptor
(Homo sapiens)
p130Cas and C3G bind PDGFR bound Crk
(Homo sapiens)
Nck binds to the active PDGF receptor
(Homo sapiens)
Grb7 binds to the active PDGF receptor
(Homo sapiens)
Participates
as an event of
Signaling by PDGF (Homo sapiens)
Orthologous Events
Downstream signal transduction (Bos taurus)
Downstream signal transduction (Caenorhabditis elegans)
Downstream signal transduction (Canis familiaris)
Downstream signal transduction (Danio rerio)
Downstream signal transduction (Drosophila melanogaster)
Downstream signal transduction (Gallus gallus)
Downstream signal transduction (Mus musculus)
Downstream signal transduction (Rattus norvegicus)
Downstream signal transduction (Sus scrofa)
Downstream signal transduction (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000288
Authored
Jassal, B (2008-11-24)
Garapati, P V (2008-11-24)
Reviewed
Heldin, CH (2008-11-24)
Created
Jassal, B (2006-08-15)
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