Crk binds to the active PDGF receptor

Stable Identifier
R-HSA-382056
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Crk family of adaptor molecules consists of CrkI with one SH2 and one SH3 domains and CrkII and CrkL with one SH2 and two SH3 domains each. They bind to Tyr762 of the PDGF alpha-receptor and represent the only known SH2-domain containing molecule which binds with significantly higher affinity to the alpha-receptor than to the beta-receptor.
Literature References
PubMed ID Title Journal Year
10508235 Mechanism of action and in vivo role of platelet-derived growth factor

Westermark, B, Heldin, CH

Physiol Rev 1999
9546424 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

Saito, Y, Saito, Y, Mori, S, Ekman, S, Hellman, U, Yokote, K, Heldin, CH, Rönnstrand, L

Oncogene 1998
9739761 Signal transduction via platelet-derived growth factor receptors

Ostman, A, Heldin, CH, Rönnstrand, L

Biochim Biophys Acta 1998
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