Crk binds to the active PDGF receptor

Stable Identifier
R-HSA-382056
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Crk family of adaptor molecules consists of CrkI with one SH2 and one SH3 domains and CrkII and CrkL with one SH2 and two SH3 domains each. They bind to Tyr762 of the PDGF alpha-receptor and represent the only known SH2-domain containing molecule which binds with significantly higher affinity to the alpha-receptor than to the beta-receptor.

Literature References
PubMed ID Title Journal Year
9546424 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

Yokote, K, Hellman, U, Ekman, S, Saito, Y, Saito, Y, Rönnstrand, L, Heldin, CH, Mori, S

Oncogene 1998
10508235 Mechanism of action and in vivo role of platelet-derived growth factor

Heldin, CH, Westermark, B

Physiol Rev 1999
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created