Reactome | PLC-gamma binds to the active receptor

PLC-gamma binds to the active receptor

Stable Identifier

R-HSA-186765

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PLC-gamma 1 has been shown to bind to phosphorylated Tyr 1021 of the PDGF beta-receptor with high affinity and to Tyr 1009 with low affinity. In the alpha-receptor, Tyr 988 and Tyr 1018 bind PLC-gamma1. Association of PLC-gamma1 with the activated PDGF receptor has been shown to be necessary for its activation.

Literature References

PubMed ID	Title	Journal	Year
8443409	Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1 Kashishian, A, Cooper, JA	Mol Biol Cell	1993
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998
1396585	Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma Arridsson, AK, Mori, S, Hellman, U, Heldin, CH, Claesson-Welsh, L, Eriksson, A, Rönnstrand, L, Wernstedt, C	EMBO J	1992