Reactome | PLC-gamma binds to the active receptor

PLC-gamma binds to the active receptor

Stable Identifier

R-HSA-186765

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PLC-gamma 1 has been shown to bind to phosphorylated Tyr 1021 of the PDGF beta-receptor with high affinity and to Tyr 1009 with low affinity. In the alpha-receptor, Tyr 988 and Tyr 1018 bind PLC-gamma1. Association of PLC-gamma1 with the activated PDGF receptor has been shown to be necessary for its activation.

Literature References

PubMed ID	Title	Journal	Year
8443409	Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1 Kashishian, A, Cooper, JA	Mol Biol Cell	1993
9739761	Signal transduction via platelet-derived growth factor receptors Heldin, CH, Ostman, A, Rönnstrand, L	Biochim Biophys Acta	1998
1396585	Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma Rönnstrand, L, Mori, S, Arridsson, AK, Eriksson, A, Wernstedt, C, Hellman, U, Claesson-Welsh, L, Heldin, CH	EMBO J	1992