Activation of Src

Stable Identifier
R-HSA-380780
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Activation of Src kinases involves displacement of Tyr527 from the SH2 domain and phosphorylation of other tyrosine residues in the kinase domain. Src activation appears to be important for the mitogenic response of PDGF.

Literature References
PubMed ID Title Journal Year
8647855 Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain

Stover, DR, Furet, P, Lydon, NB

J Biol Chem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created