Activation of Src

Stable Identifier
R-HSA-380780
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of Src
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Activation of Src kinases involves displacement of Tyr527 from the SH2 domain and phosphorylation of other tyrosine residues in the kinase domain. Src activation appears to be important for the mitogenic response of PDGF.

Literature References
PubMed ID Title Journal Year
8647855 Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain

Stover, DR, Furet, P, Lydon, NB

J Biol Chem 1996
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane]

Physical Entity
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Activation of Src (Bos taurus)
Activation of Src (Caenorhabditis elegans)
Activation of Src (Canis familiaris)
Activation of Src (Danio rerio)
Activation of Src (Drosophila melanogaster)
Activation of Src (Gallus gallus)
Activation of Src (Mus musculus)
Activation of Src (Rattus norvegicus)
Activation of Src (Sus scrofa)
Activation of Src (Xenopus tropicalis)
Authored
Jassal, B  (2008-11-24)
Garapati, P V  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Garapati, P V  (2008-11-14)
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