Phosphorylation of PLCgamma by PDGFR

Stable Identifier
R-HSA-1524186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The activated PDGF receptor phosphorylates PLCgamma on tyrosine residues 472,771,783 and 1254, activating the enzyme.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Suh, PG, Rhee, SG, Hunter, T

Cell 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created