Phosphorylation of PLCgamma by PDGFR

Stable Identifier
R-HSA-1524186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Phosphorylation of PLCgamma by PDGFR
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The activated PDGF receptor phosphorylates PLCgamma on tyrosine residues 472,771,783 and 1254, activating the enzyme.
Literature References
PubMed ID Title Journal Year
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Rhee, SG, Suh, PG, Hunter, T

Cell 1989
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane]

Physical Entity
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of PLCgamma by PDGFR (Bos taurus)
Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)
Phosphorylation of PLCgamma by PDGFR (Canis familiaris)
Phosphorylation of PLCgamma by PDGFR (Danio rerio)
Phosphorylation of PLCgamma by PDGFR (Drosophila melanogaster)
Phosphorylation of PLCgamma by PDGFR (Gallus gallus)
Phosphorylation of PLCgamma by PDGFR (Mus musculus)
Phosphorylation of PLCgamma by PDGFR (Rattus norvegicus)
Phosphorylation of PLCgamma by PDGFR (Sus scrofa)
Phosphorylation of PLCgamma by PDGFR (Xenopus tropicalis)
Authored
Rothfels, K  (2011-08-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Rothfels, K  (2011-08-24)
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