SOS is the guanine nucleotide exchange factor (GEF) for RAS. SOS activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).
Ostman, A, Heldin, CH, Rönnstrand, L
Satoh, T, Escobedo, JA, Kaziro, Y, Williams, LT, Fantl, WJ
guanyl-nucleotide exchange factor activity of PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane]
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