Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)

Stable Identifier
R-HSA-186834
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)
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SOS is the guanine nucleotide exchange factor (GEF) for Ras. SOS activates Ras nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).

Literature References
PubMed ID Title Journal Year
8388543 Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types

Satoh, T, Fantl, WJ, Escobedo, JA, Williams, LT, Kaziro, Y

Mol Cell Biol 1993
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane]
Physical Entity
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane]
Activity
Ras guanyl-nucleotide exchange factor activity (0005088)
Orthologous Events
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Bos taurus)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Caenorhabditis elegans)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Canis familiaris)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Danio rerio)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Drosophila melanogaster)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Gallus gallus)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Mus musculus)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Rattus norvegicus)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Sus scrofa)
Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) (Xenopus tropicalis)
Authored
Garapati, P V  (2008-11-24)
Jassal, B  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Jassal, B  (2006-08-24)