SOS is the guanine nucleotide exchange factor (GEF) for RAS. SOS activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).
Satoh, T, Fantl, WJ, Escobedo, JA, Williams, LT, Kaziro, Y
Heldin, CH, Ostman, A, Rönnstrand, L
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