Reactome | SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)

SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)

Stable Identifier

R-HSA-186834

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)

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SOS is the guanine nucleotide exchange factor (GEF) for RAS. SOS activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).

Literature References

PubMed ID	Title	Journal	Year
8388543	Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types Satoh, T, Fantl, WJ, Escobedo, JA, Williams, LT, Kaziro, Y	Mol Cell Biol	1993
9739761	Signal transduction via platelet-derived growth factor receptors Heldin, CH, Ostman, A, Rönnstrand, L	Biochim Biophys Acta	1998