PI3K catalyses the phosphorylation of PIP2 to PIP3

Stable Identifier
R-HSA-186800
Type
Reaction
Species
Homo sapiens
Compartment
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The preferred substrate of PI3K is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] (PIP2), which is phosphorylated to the trisphosphate [PI(3,4,5)P3] (PIP3). PI3-kinase and its products have been found to be of importance in PDGF-stimulated actin reorganization, and directed cell movement, as well as in the stimulation of cell growth and inhibition of apoptosis.

Participants
Participates
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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