Nck binds to the active PDGF receptor

Stable Identifier
R-HSA-382058
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction have not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
10508235 Mechanism of action and in vivo role of platelet-derived growth factor

Heldin, CH, Westermark, B

Physiol Rev 1999
7692233 Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

Nishimura, R, Li, W, Kashishian, A, Mondino, A, Zhou, M, Cooper, J, Schlessinger, J

Mol Cell Biol 1993
Participants
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Orthologous Events
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