Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction have not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK.
Heldin, CH, Ostman, A, Rönnstrand, L
Heldin, CH, Westermark, B
Nishimura, R, Li, W, Kashishian, A, Mondino, A, Zhou, M, Cooper, J, Schlessinger, J
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