Reactome | Nck binds to the active PDGF receptor

Nck binds to the active PDGF receptor

Stable Identifier

R-HSA-382058

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction have not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK.

Literature References

PubMed ID	Title	Journal	Year
10508235	Mechanism of action and in vivo role of platelet-derived growth factor Westermark, B, Heldin, CH	Physiol Rev	1999
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998
7692233	Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor Schlessinger, J, Mondino, A, Zhou, M, Cooper, J, Nishimura, R, Kashishian, A, Li, W	Mol Cell Biol	1993