Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction have not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK.
Westermark, B, Heldin, CH
Ostman, A, Heldin, CH, Rönnstrand, L
Schlessinger, J, Mondino, A, Zhou, M, Cooper, J, Nishimura, R, Kashishian, A, Li, W
© 2023 Reactome