The Src family of tyrosine kinases are characterized by a SH3 and a SH2 domain in addition to the kinase domain.Src is activated when the SH2 domain binds to autophosphorylation sites on PDGF receptors (Tyr579 and 581 in the beta-receptor, Tyr572 and 574 in the alpha receptor), in conjuction with dephosporylation of the COOH-terminal phosphorylated tyrosine 527.
Westermark, B, Heldin, CH
Bazenet, C, Kazlauskas, A, Gelderloos, JA, Rosenkranz, S
Ostman, A, Heldin, CH, Rönnstrand, L
Engström, A, Mori, S, Courtneidge, SA, Yokote, K, Heldin, CH, Claesson-Welsh, L, Rönnstrand, L
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