Reactome | SH2 domain of Src binds to the active receptor

SH2 domain of Src binds to the active receptor

Stable Identifier

R-HSA-186819

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SH2 domain of Src binds to the active receptor

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The Src family of tyrosine kinases are characterized by a SH3 and a SH2 domain in addition to the kinase domain.Src is activated when the SH2 domain binds to autophosphorylation sites on PDGF receptors (Tyr579 and 581 in the beta-receptor, Tyr572 and 574 in the alpha receptor), in conjuction with dephosporylation of the COOH-terminal phosphorylated tyrosine 527.

Literature References

PubMed ID	Title	Journal	Year
10508235	Mechanism of action and in vivo role of platelet-derived growth factor Westermark, B, Heldin, CH	Physiol Rev	1999
9488729	A role for Src in signal relay by the platelet-derived growth factor alpha receptor Bazenet, C, Kazlauskas, A, Gelderloos, JA, Rosenkranz, S	J Biol Chem	1998
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998
7685273	Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases Engström, A, Mori, S, Courtneidge, SA, Yokote, K, Heldin, CH, Claesson-Welsh, L, Rönnstrand, L	EMBO J	1993