Reactome | SH2 domain of Src binds to the active receptor

SH2 domain of Src binds to the active receptor

Stable Identifier

R-HSA-186819

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SH2 domain of Src binds to the active receptor

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Src family of tyrosine kinases are characterized by a SH3 and a SH2 domain in addition to the kinase domain.Src is activated when the SH2 domain binds to autophosphorylation sites on PDGF receptors (Tyr579 and 581 in the beta-receptor, Tyr572 and 574 in the alpha receptor), in conjuction with dephosporylation of the COOH-terminal phosphorylated tyrosine 527.

Literature References

PubMed ID	Title	Journal	Year
10508235	Mechanism of action and in vivo role of platelet-derived growth factor Westermark, B, Heldin, CH	Physiol Rev	1999
9488729	A role for Src in signal relay by the platelet-derived growth factor alpha receptor Bazenet, C, Kazlauskas, A, Gelderloos, JA, Rosenkranz, S	J Biol Chem	1998
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998
7685273	Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases Engström, A, Mori, S, Courtneidge, SA, Yokote, K, Heldin, CH, Claesson-Welsh, L, Rönnstrand, L	EMBO J	1993