p130Cas and C3G bind PDGFR bound Crk

Stable Identifier
Reaction [binding]
Homo sapiens
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The presence of both SH2 and SH3 domains in Crk proteins is of crucial importance for their function as adaptor molecules. Crk forms complex with Cas, an SH3 domain-containing docking protein which has been shown to be phosphorylated after PDGF-stimulation of cells, and C3G, a nucleotide exchange protein which has been linked to the activation of JNK.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
9546424 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins

Yokote, K, Hellman, U, Ekman, S, Saito, Y, Saito, Y, Rönnstrand, L, Heldin, CH, Mori, S

Oncogene 1998
Participant Of
Orthologous Events
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