PI3-kinase binds to the active receptor

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphatidylinositol 3'-kinases (PI3Ks) are a family of enzymes which can phosphorylate phosphoinositides. PI3Ks bind to and are activated by PDGF receptors. Tyr 740 and Tyr 751 in PDGF beta-receptor, and Tyr 731 and Tyr 742 in PDGF alpha-receptor have been shown to be autophosphorylation sites and to bind PI3-kinase.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
2466336 Role of phosphatidylinositol kinase in PDGF receptor signal transduction

Coughlin, SR, Escobedo, JA, Williams, LT

Science 1989
1374684 Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

Fantl, WJ, Escobedo, JA, Martin, GA, Turck, CW, del Rosario, M, McCormick, F, Williams, LT

Cell 1992
Participant Of
Orthologous Events
Cite Us!