PI3-kinase binds to the active receptor

Stable Identifier
R-HSA-186780
Type
Reaction [binding]
Species
Homo sapiens
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Phosphatidylinositol 3'-kinases (PI3Ks) are a family of enzymes which can phosphorylate phosphoinositides. These bind to and are activated by PDGF receptors. Tyr 740 and tyr 751 in PDGF beta-receptor, and tyr 731 and tyr 742 in PDGF alpha-receptor have been shown to be autophosphorylation sites and to bind PI3-kinase.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
2466336 Role of phosphatidylinositol kinase in PDGF receptor signal transduction

Coughlin, SR, Escobedo, JA, Williams, LT

Science 1989
1374684 Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

Fantl, WJ, Escobedo, JA, Martin, GA, Turck, CW, del Rosario, M, McCormick, F, Williams, LT

Cell 1992
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