Reactome | PI3-kinase binds to the active receptor

PI3-kinase binds to the active receptor

Stable Identifier

R-HSA-186780

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphatidylinositol 3'-kinases (PI3Ks) are a family of enzymes which can phosphorylate phosphoinositides. PI3Ks bind to and are activated by PDGF receptors. Tyr 740 and Tyr 751 in PDGF beta-receptor, and Tyr 731 and Tyr 742 in PDGF alpha-receptor have been shown to be autophosphorylation sites and to bind PI3-kinase.

Literature References

PubMed ID	Title	Journal	Year
2466336	Role of phosphatidylinositol kinase in PDGF receptor signal transduction Coughlin, SR, Escobedo, JA, Williams, LT	Science	1989
9739761	Signal transduction via platelet-derived growth factor receptors Heldin, CH, Ostman, A, Rönnstrand, L	Biochim Biophys Acta	1998
1374684	Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways Fantl, WJ, Escobedo, JA, Martin, GA, Turck, CW, del Rosario, M, McCormick, F, Williams, LT	Cell	1992