GRB2:SOS1 complex binds to the active receptor

Stable Identifier
Homo sapiens
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GRB2 is an adaptor molecule containing one SH2 domain and two SH3 domains. The SH2 domain of GRB2 binds directly to autophosphorylated PDGF receptors and with its SH3 domain it forms a complex with SOS1. The binding of GRB2:SOS1 to the PDGF receptor juxtaposes the complex towards RAS molecules leading to RAS activation. RAS activates the MAP kinase cascade, a pathway implicated in cell growth stimulation, migration and differentiation.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Ostman, A, Heldin, CH, Rönnstrand, L

Biochim Biophys Acta 1998
8388543 Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types

Satoh, T, Escobedo, JA, Kaziro, Y, Williams, LT, Fantl, WJ

Mol Cell Biol 1993
7935391 Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

Arvidsson, AK, Wennström, S, Downward, J, Schlessinger, J, Rupp, E, Heldin, CH, Claesson-Welsh, L, Nånberg, E, Rönnstrand, L

Mol Cell Biol 1994
Orthologous Events
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