Reactome | GRB2:SOS1 complex binds to the active receptor

GRB2:SOS1 complex binds to the active receptor

Stable Identifier

R-HSA-186826

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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GRB2:SOS1 complex binds to the active receptor

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GRB2 is an adaptor molecule containing one SH2 domain and two SH3 domains. The SH2 domain of GRB2 binds directly to autophosphorylated PDGF receptors and with its SH3 domain it forms a complex with SOS1. The binding of GRB2:SOS1 to the PDGF receptor juxtaposes the complex towards RAS molecules leading to RAS activation. RAS activates the MAP kinase cascade, a pathway implicated in cell growth stimulation, migration and differentiation.

Literature References

PubMed ID	Title	Journal	Year
9739761	Signal transduction via platelet-derived growth factor receptors Heldin, CH, Ostman, A, Rönnstrand, L	Biochim Biophys Acta	1998
8388543	Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types Satoh, T, Fantl, WJ, Escobedo, JA, Williams, LT, Kaziro, Y	Mol Cell Biol	1993
7935391	Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation Arvidsson, AK, Rupp, E, Nånberg, E, Downward, J, Rönnstrand, L, Wennström, S, Schlessinger, J, Heldin, CH, Claesson-Welsh, L	Mol Cell Biol	1994