Grb7 binds to the active PDGF receptor

Stable Identifier
R-HSA-382055
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Grb7 an adapter protein contains a single SH2 domain, a pleckstrin homology (PH) domain, and a proline-rich region. Similar to Grb2, Grb7 interacts with phosphorylated tyrosines in pYXNX motifs, including Tyr716 and Tyr775 of the PDGF beta-receptor.

Literature References
PubMed ID Title Journal Year
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
10508235 Mechanism of action and in vivo role of platelet-derived growth factor

Heldin, CH, Westermark, B

Physiol Rev 1999
8940081 Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors

Yokote, K, Margolis, B, Heldin, CH, Claesson-Welsh, L

J Biol Chem 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created