Reactome | Grb7 binds to the active PDGF receptor

Grb7 binds to the active PDGF receptor

Stable Identifier

R-HSA-382055

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Grb7 an adapter protein contains a single SH2 domain, a pleckstrin homology (PH) domain, and a proline-rich region. Similar to Grb2, Grb7 interacts with phosphorylated tyrosines in pYXNX motifs, including Tyr716 and Tyr775 of the PDGF beta-receptor.

Literature References

PubMed ID	Title	Journal	Year
10508235	Mechanism of action and in vivo role of platelet-derived growth factor Westermark, B, Heldin, CH	Physiol Rev	1999
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998
8940081	Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors Yokote, K, Heldin, CH, Claesson-Welsh, L, Margolis, B	J Biol Chem	1996