Grb7 binds to the active PDGF receptor

Stable Identifier
R-HSA-382055
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Grb7 binds to the active PDGF receptor
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Grb7 an adapter protein contains a single SH2 domain, a pleckstrin homology (PH) domain, and a proline-rich region. Similar to Grb2, Grb7 interacts with phosphorylated tyrosines in pYXNX motifs, including Tyr716 and Tyr775 of the PDGF beta-receptor.

Literature References
PubMed ID Title Journal Year
10508235 Mechanism of action and in vivo role of platelet-derived growth factor

Westermark, B, Heldin, CH

Physiol Rev 1999
9739761 Signal transduction via platelet-derived growth factor receptors

Ostman, A, Heldin, CH, Rönnstrand, L

Biochim Biophys Acta 1998
8940081 Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors

Yokote, K, Heldin, CH, Claesson-Welsh, L, Margolis, B

J Biol Chem 1996
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Authored
Jassal, B  (2008-11-24)
Garapati, P V  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-23)
Created
Garapati, P V  (2008-11-21)
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