STAT binds to the active receptor

Stable Identifier
Reaction [binding]
Homo sapiens
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Among the seven members of the STAT family, STAT1, STAT3, STAT5 alpha and -beta, and STAT6 have been shown to bind to the activated PDGF beta-receptor (PDGFRB) and to be phosphorylated after PDGF stimulation; binding also occurs to the alpha-receptor (PDGFRA), albeit only weakly.

Literature References
PubMed ID Title Journal Year
8657151 Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins

Vignais, ML, Sadowski, HB, Watling, D, Rogers, NC, Gilman, M

Mol Cell Biol 1996
9739761 Signal transduction via platelet-derived growth factor receptors

Heldin, CH, Ostman, A, Rönnstrand, L

Biochim Biophys Acta 1998
9484840 Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains

Valgeirsdóttir, S, Paukku, K, Silvennoinen, O, Heldin, CH, Claesson-Welsh, L

Oncogene 1998
Participant Of
Orthologous Events
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