Reactome | STAT binds to the active receptor

STAT binds to the active receptor

Stable Identifier

R-HSA-380782

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Among the seven members of the STAT family, STAT1, STAT3, STAT5 alpha and -beta, and STAT6 have been shown to bind to the activated PDGF beta-receptor (PDGFRB) and to be phosphorylated after PDGF stimulation; binding also occurs to the alpha-receptor (PDGFRA), albeit only weakly.

Literature References

PubMed ID	Title	Journal	Year
8657151	Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins Vignais, ML, Sadowski, HB, Watling, D, Rogers, NC, Gilman, M	Mol Cell Biol	1996
9739761	Signal transduction via platelet-derived growth factor receptors Heldin, CH, Ostman, A, Rönnstrand, L	Biochim Biophys Acta	1998
9484840	Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains Valgeirsdóttir, S, Paukku, K, Silvennoinen, O, Heldin, CH, Claesson-Welsh, L	Oncogene	1998