Activated PLC gamma dissociates from the PDGF receptor

Stable Identifier
R-HSA-1524182
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Activated PLC gamma dissociates from the PDGF receptor
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Once phosphorylated, PLCgamma dissociates from the receptor. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.
Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
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Authored
Rothfels, K  (2011-08-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Rothfels, K  (2011-08-24)
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