GTPase-activating protein (GAP) has two SH2 domains which bind only to PDGF beta-receptors on Tyr771. GAP does not bind the alpha-receptor. GAP converts Ras-GTP to Ras-GDP, deactivating Ras.
Heldin, CH, Ostman, A, Rönnstrand, L
Kashishian, A, Kazlauskas, A, Cooper, JA
Kazlauskas, A, Kashishian, A, Cooper, JA, Valius, M
© 2021 Reactome