GAP binds to PDGF-beta receptors only

Stable Identifier
R-HSA-186798
Type
Reaction
Species
Homo sapiens
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GTPase-activating protein (GAP) has two SH2 domains which bind only to PDGF beta-receptors on Tyr771. GAP does not bind the alpha-receptor. GAP converts Ras-GTP to Ras-GDP, deactivating Ras.

Literature References
PubMed ID Title Journal Year
1314164 Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo

Kazlauskas, A, Kashishian, A, Cooper, JA

EMBO J 1992
9739761 Signal transduction via platelet-derived growth factor receptors

Ostman, A, Heldin, CH, Rönnstrand, L

Biochim Biophys Acta 1998
1375321 GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

Kazlauskas, A, Valius, M, Kashishian, A, Cooper, JA

Mol Cell Biol 1992
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