Reactome | GAP binds to PDGF-beta receptors only

GAP binds to PDGF-beta receptors only

Stable Identifier

R-HSA-186798

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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GTPase-activating protein (GAP) has two SH2 domains which bind only to PDGF beta-receptors on Tyr771. GAP does not bind the alpha-receptor. GAP converts Ras-GTP to Ras-GDP, deactivating Ras.

Literature References

PubMed ID	Title	Journal	Year
9739761	Signal transduction via platelet-derived growth factor receptors Heldin, CH, Ostman, A, Rönnstrand, L	Biochim Biophys Acta	1998
1314164	Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo Kashishian, A, Kazlauskas, A, Cooper, JA	EMBO J	1992
1375321	GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit Kazlauskas, A, Kashishian, A, Cooper, JA, Valius, M	Mol Cell Biol	1992