Reactome | GAP binds to PDGF-beta receptors only

GAP binds to PDGF-beta receptors only

Stable Identifier

R-HSA-186798

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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GTPase-activating protein (GAP) has two SH2 domains which bind only to PDGF beta-receptors on Tyr771. GAP does not bind the alpha-receptor. GAP converts Ras-GTP to Ras-GDP, deactivating Ras.

Literature References

PubMed ID	Title	Journal	Year
1314164	Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo Kazlauskas, A, Kashishian, A, Cooper, JA	EMBO J	1992
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998
1375321	GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit Kazlauskas, A, Valius, M, Kashishian, A, Cooper, JA	Mol Cell Biol	1992