Reactome | Rpn12 [nucleoplasm]

Rpn12 [nucleoplasm]

Stable Identifier

R-DME-174318

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

PSMD8, Q9V436

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G1/S DNA Damage Checkpoints (Drosophila melanogaster)
    - p53-Independent G1/S DNA Damage Checkpoint (Drosophila melanogaster)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Cyclin E associated events during G1/S transition (Drosophila melanogaster)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)
  - Regulation of mitotic cell cycle (Drosophila melanogaster)
    - APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Drosophila melanogaster)
        
        Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
      - SCF(Skp2)-mediated degradation of p27/p21 (Drosophila melanogaster)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Drosophila melanogaster)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional regulation by RUNX2 (Drosophila melanogaster)
      - Regulation of RUNX2 expression and activity (Drosophila melanogaster)
        
        26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional regulation by RUNX3 (Drosophila melanogaster)
      - Regulation of RUNX3 expression and activity (Drosophila melanogaster)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)
        
        26S proteasome [nucleoplasm] (Drosophila melanogaster)
        
        19S regulatory particle [nucleoplasm] (Drosophila melanogaster)
        
        19S RP lid [nucleoplasm] (Drosophila melanogaster)
        
        Rpn12 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V436 Rpn12

Gene Names

Rpn12, CG4157, Dmel_CG4157

Reference Genes

BioGPS Gene:39845 Rpn12

CTD Gene:39845 Rpn12

KEGG:dme:Dmel_CG4157 Rpn12

Monarch:39845 Rpn12

NCBI Gene:39845 Rpn12

UCSC:Q9V436 Rpn12

Reference Transcript

RefSeq:NM_140647.4 Rpn12

Other Identifiers

144246_at

1640372_at

39845

GO:0000502

GO:0003674

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0006508

GO:0006511

GO:0008541

GO:0030163

GO:0043161

Participates

as a component of

19S RP lid [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

RPN12 [nucleoplasm]

RPN12 [cytosol]

Rpn12 [cytosol]

Inferred From

PSMD8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_648904.1

FlyBase

FBgn0028693

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12881 Prosalpha6	4	PROS35 [nucleoplasm] (R-DME-216129) PROS35 [cytosol] (R-DME-206188) Prosalpha6 [nucleoplasm] (R-DME-174333) Prosalpha6 [cytosol] (R-DME-68724)	0.547	2
UniProt:P26270 Rpn8	7	MOV34 [nucleoplasm] (R-DME-216236) MOV34 [cytosol] (R-DME-206270) Rpn8 [secretory granule lumen] (R-DME-6801008) Rpn8 [extracellular region] (R-DME-6806488) Rpn8 [ficolin-1-rich granule lumen] (R-DME-6800406) Rpn8 [nucleoplasm] (R-DME-174309) Rpn8 [cytosol] (R-DME-68806)	0.547	2
UniProt:Q8IH42 Q8IH42			0.488	2

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