Reactome | rpn-12 [nucleoplasm]

rpn-12 [nucleoplasm]

Stable Identifier

R-CEL-174318

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

PSMD8, Q23449

Locations in the PathwayBrowser

Expand all

Cell Cycle (Caenorhabditis elegans)

- Cell Cycle Checkpoints (Caenorhabditis elegans)
  - G1/S DNA Damage Checkpoints (Caenorhabditis elegans)
    - p53-Independent G1/S DNA Damage Checkpoint (Caenorhabditis elegans)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Caenorhabditis elegans)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        rpn-12 [nucleoplasm] (Caenorhabditis elegans)
- Cell Cycle, Mitotic (Caenorhabditis elegans)
  - Mitotic G1 phase and G1/S transition (Caenorhabditis elegans)
    - G1/S Transition (Caenorhabditis elegans)
      - Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        rpn-12 [nucleoplasm] (Caenorhabditis elegans)
  - S Phase (Caenorhabditis elegans)
    - Cyclin A:Cdk2-associated events at S phase entry (Caenorhabditis elegans)
      - SCF(Skp2)-mediated degradation of p27/p21 (Caenorhabditis elegans)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        rpn-12 [nucleoplasm] (Caenorhabditis elegans)

Cellular responses to stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Cellular response to chemical stress (Caenorhabditis elegans)
    - KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
      - Nuclear events mediated by NFE2L2 (Caenorhabditis elegans)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Caenorhabditis elegans)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        rpn-12 [nucleoplasm] (Caenorhabditis elegans)

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - Transcriptional regulation by RUNX2 (Caenorhabditis elegans)
      - Regulation of RUNX2 expression and activity (Caenorhabditis elegans)
        
        26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        rpn-12 [nucleoplasm] (Caenorhabditis elegans)
    - Transcriptional regulation by RUNX3 (Caenorhabditis elegans)
      - Regulation of RUNX3 expression and activity (Caenorhabditis elegans)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Caenorhabditis elegans)
        
        26S proteasome [nucleoplasm] (Caenorhabditis elegans)
        
        19S regulatory particle [nucleoplasm] (Caenorhabditis elegans)
        
        19S RP lid [nucleoplasm] (Caenorhabditis elegans)
        
        rpn-12 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q23449

Gene Names

rpn-12

Reference Genes

BioGPS Gene:174786 rpn-12

ENSEMBL:WBGene00004468

KEGG:cel:CELE_ZK20.5 rpn-12

Monarch:174786 rpn-12

NCBI Gene:174786 rpn-12

UCSC:Q23449 rpn-12

Wormbase:WBGene00004468

Wormbase:WBGene00004468 rpn-12

Reference Transcript

RefSeq:NM_064088.10 rpn-12

Other Identifiers

174786

GO:0000502

GO:0005515

GO:0005634

GO:0005838

GO:0006508

GO:0008541

GO:0030163

GO:0043161

Participates

as a component of

19S RP lid [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

rpn-12 [cytosol]

Inferred From

PSMD8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_496489.1

ENSEMBL

ZK20.5.1, ZK20.5.1, WBGene00004468

PRO

Q23449

Cite Us!