Reactome | PKMYT1 [nucleoplasm]

PKMYT1 [nucleoplasm]

Stable Identifier

R-HSA-74386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Myt1 kinase

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External Reference Information

External Reference

UniProt:Q99640 PKMYT1

Gene Names

PKMYT1, MYT1

Chain

chain:1-499

Reference Genes

BioGPS Gene:9088 PKMYT1

COSMIC (genes):MYT1 PKMYT1

COSMIC (genes):PKMYT1 PKMYT1

CTD Gene:9088 PKMYT1

dbSNP Gene:9088 PKMYT1

ENSEMBL:ENSG00000127564 PKMYT1

HGNC:29650 PKMYT1

KEGG:hsa:9088 PKMYT1

Monarch:9088 PKMYT1

NCBI Gene:9088 PKMYT1

OMIM:602474 PKMYT1

UCSC:Q99640 PKMYT1

Reference Transcript

Participates

as an input of

Inactivation of Myt1 kinase (Homo sapiens)

Other forms of this molecule

p-PKMYT1 [nucleoplasm]

PKMYT1 [cytosol]

Inferred To

Homologues of PKMYT1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of PKMYT1 [nucleoplasm] (Schizosaccharomyces pombe)

PKMYT1 [nucleoplasm] (Bos taurus)

PKMYT1 [nucleoplasm] (Caenorhabditis elegans)

PKMYT1 [nucleoplasm] (Canis familiaris)

PKMYT1 [nucleoplasm] (Danio rerio)

PKMYT1 [nucleoplasm] (Dictyostelium discoideum)

PKMYT1 [nucleoplasm] (Drosophila melanogaster)

PKMYT1 [nucleoplasm] (Mus musculus)

PKMYT1 [nucleoplasm] (Saccharomyces cerevisiae)

PKMYT1 [nucleoplasm] (Schizosaccharomyces pombe)

PKMYT1 [nucleoplasm] (Sus scrofa)

Pkmyt1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001245380.1, XP_011521037.1, NP_001245379.1, NP_872629.1, XP_011521036.1, XP_011521038.1, NP_004194.3

Guide to Pharmacology - Targets

2167

OpenTargets

ENSG00000127564

ENSEMBL

ENSP00000459123, ENSP00000262300, ENST00000262300, ENST00000573944, ENST00000574385, ENSP00000460868, ENSG00000127564, ENSP00000458943, ENST00000574730, ENSP00000397739, ENST00000440027

ZINC - FDA approved

PMYT1_HUMAN

ZINC - Substances

PMYT1_HUMAN

ZINC target

Q99640

PRO

Q99640

PDB

8ZU2, 8D6C, 8ZUL, 8D6E, 8WJY, 5VD0, 5VCZ, 5VD3, 8D6F, 5VCY, 5VCX, 8ZTX, 8ZUD, 5VD1, 5VCV, 5VCW, 8D6D, 3P1A

ZINC - Investigational

PMYT1_HUMAN

HPA

ENSG00000127564-PKMYT1

GeneCards

PKMYT1

Pharos - Targets

Q99640

ZINC - Predictions - Purchasable

PMYT1_HUMAN

HMDB Protein

HMDBP01378

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.893	9
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.867	8
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.725	5
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.725	6
UniProt:P33552 CKS2			0.725	4
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.643	3
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.564	3
UniProt:P24394 IL4R	2	p-Y-IL4R [plasma membrane] (R-HSA-6786087) IL4R [plasma membrane] (R-HSA-449670)	0.527	2
UniProt:O43291 SPINT2	1	SPINT2 [extracellular region] (R-HSA-6800233)	0.527	2

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