Reactome | ALYREF [nucleoplasm]

ALYREF [nucleoplasm]

Stable Identifier

R-HSA-156649

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

THOC4(Aly/Ref)

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        ALYREF [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
        
        ALYREF [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        ALYREF [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
        
        ALYREF [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86V81 ALYREF

Gene Names

ALYREF, ALY, BEF, THOC4

Chain

initiator methionine:, chain:2-257

Reference Genes

BioGPS Gene:10189 ALYREF

COSMIC (genes):ALYREF ALYREF

CTD Gene:10189 ALYREF

dbSNP Gene:10189 ALYREF

ENSEMBL:ENSG00000183684 ALYREF

HGNC:19071 ALYREF

KEGG Gene (Homo sapiens):10189 ALYREF

Monarch:10189 ALYREF

NCBI Gene:10189 ALYREF

OMIM:604171 ALYREF

Reference Transcript

RefSeq:NM_005782.3 ALYREF

Participates

as a component of

as an input of

as a member of

ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

ALYREF [cytosol]

Inferred To

alyref [nucleoplasm] (Danio rerio)

alyref [nucleoplasm] (Xenopus tropicalis)

Ref1 [nucleoplasm] (Drosophila melanogaster)

aly-3 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of ALYREF [nucleoplasm] (Saccharomyces cerevisiae)

Alyref [nucleoplasm] (Mus musculus)

Alyref [nucleoplasm] (Rattus norvegicus)

ALYREF [nucleoplasm] (Bos taurus)

ALYREF [nucleoplasm] (Canis familiaris)

ALYREF [nucleoplasm] (Dictyostelium discoideum)

ALYREF [nucleoplasm] (Gallus gallus)

ALYREF [nucleoplasm] (Plasmodium falciparum)

ALYREF [nucleoplasm] (Schizosaccharomyces pombe)

ALYREF [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005773.3

OpenTargets

ENSG00000183684

GeneCards

Q86V81

PRO

Q86V81

Pharos - Targets

Q86V81

PDB

3ULH, 7ZNJ, 7ZNK

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13838 DDX39B	2	DDX39B [cytosol] (R-HSA-9715154) DDX39B [nucleoplasm] (R-HSA-8849139)	0.768	5
UniProt:Q96FV9 THOC1	1	THOC1 [nucleoplasm] (R-HSA-8849130)	0.749	7
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.656	4
UniProt:Q8NI27 THOC2	1	THOC2 [nucleoplasm] (R-HSA-8849134)	0.643	4
UniProt:Q53F19 NCBP3			0.643	6
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.643	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.639	5
UniProt:Q13769 THOC5	3	THOC5 [nucleoplasm] (R-HSA-8849111) THOC5 [cytosol] (R-HSA-9682751) p-Y-THOC5 [cytosol] (R-HSA-9682738)	0.623	5
UniProt:Q2HR75 MTA			0.621	4
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.597	3
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.558	8
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.527	2
UniProt:Q9H1J1 UPF3A	1	UPF3A [cytosol] (R-HSA-927801)	0.527	2
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:Q6I9Y2 THOC7	1	THOC7 [nucleoplasm] (R-HSA-8849145)	0.527	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.499	4
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2

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