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ALYREF [nucleoplasm]
Stable Identifier
R-HSA-156649
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
THOC4(Aly/Ref)
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Transport of the SLBP Dependant Mature mRNA (Homo sapiens)
Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Homo sapiens)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
ALYREF, FYTTD1, LUZP4 [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
EJC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C (Bact) complex (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal A Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B Complex (Homo sapiens)
Spliceosomal A Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliceosomal B Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliceosomal E Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C (B*) complex (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
ALYREF [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86V81 ALYREF
Gene Names
ALYREF, ALY, BEF, THOC4
Chain
initiator methionine:1, chain:2-257
Reference Genes
BioGPS Gene:10189 ALYREF
COSMIC (genes):ALYREF ALYREF
CTD Gene:10189 ALYREF
dbSNP Gene:10189 ALYREF
ENSEMBL:ENSG00000183684 ALYREF
HGNC:19071 ALYREF
KEGG Gene (Homo sapiens):10189 ALYREF
Monarch:10189 ALYREF
NCBI Gene:10189 ALYREF
OMIM:604171 ALYREF
Reference Transcript
RefSeq:NM_005782.3 ALYREF
Participant Of
input
Docking of Mature Histone mRNA complex:TAP at the NPC
Docking of Mature Replication Dependent Histone mRNA with the NPC
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
Formation of the Spliceosomal E complex
hasComponent
EJC [nucleoplasm]
Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex [nucleoplasm]
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex [nucleoplasm]
Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex [nucleoplasm]
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm]
Spliceosomal A Complex [nucleoplasm]
Spliceosomal Active C (B*) Complex [nucleoplasm]
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm]
Spliceosomal B Complex [nucleoplasm]
Spliceosomal E Complex [nucleoplasm]
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
hasMember
ALYREF, FYTTD1, LUZP4 [nucleoplasm]
Other forms of this molecule
ALYREF [cytosol]
Inferred To
alyref [nucleoplasm] (Danio rerio)
alyref [nucleoplasm] (Xenopus tropicalis)
Ref1 [nucleoplasm] (Drosophila melanogaster)
YRA1 [nucleoplasm] (Saccharomyces cerevisiae)
aly-3 [nucleoplasm] (Caenorhabditis elegans)
mlo3 [nucleoplasm] (Schizosaccharomyces pombe)
Alyref [nucleoplasm] (Mus musculus)
Alyref [nucleoplasm] (Rattus norvegicus)
ALYREF [nucleoplasm] (Bos taurus)
ALYREF [nucleoplasm] (Canis familiaris)
ALYREF [nucleoplasm] (Dictyostelium discoideum)
ALYREF [nucleoplasm] (Gallus gallus)
ALYREF [nucleoplasm] (Sus scrofa)
Cross References
RefSeq
NP_005773.3
OpenTargets
ENSG00000183684
GeneCards
Q86V81
PRO
Q86V81
PDB
3ULH
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96FV9 THOC1
1
THOC1 [nucleoplasm]
(R-HSA-8849130)
0.749
7
UniProt:Q13838 DDX39B
1
DDX39B [nucleoplasm]
(R-HSA-8849139)
0.702
4
UniProt:Q9UBU9 NXF1
2
NXF1 [nucleoplasm]
(R-HSA-111690)
NXF1 [cytosol]
(R-HSA-156481)
0.656
4
UniProt:Q8NI27 THOC2
1
THOC2 [nucleoplasm]
(R-HSA-8849134)
0.643
4
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.639
5
UniProt:Q13769 THOC5
1
THOC5 [nucleoplasm]
(R-HSA-8849111)
0.623
5
UniProt:Q2HR75 ICP27
0.621
4
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.597
3
UniProt:Q9Y3Y2 CHTOP
1
CHTOP [nucleoplasm]
(R-HSA-8849147)
0.558
8
UniProt:Q9H1J1 UPF3A
1
UPF3A [cytosol]
(R-HSA-927801)
0.527
2
UniProt:Q07021 C1QBP
3
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [cytosol]
(R-HSA-9645690)
0.527
2
UniProt:Q6I9Y2 THOC7
1
THOC7 [nucleoplasm]
(R-HSA-8849145)
0.527
2
UniProt:P06493 CDK1
10
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
CDK1 [cytosol]
(R-HSA-170075)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
0.499
4
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